Cytokine-Enhanced Vaccine and Interferon-β plus Suicide Gene Therapy as Surgery Adjuvant Treatments for Spontaneous Canine Melanoma

Human Gene Therapy
Liliana María Elena FinocchiaroGerardo Claudio Glikin

Abstract

We present here a nonviral immunogene therapy trial for canine malignant melanoma, an aggressive disease displaying significant clinical and histopathological overlapping with human melanoma. As a surgery adjuvant approach, it comprised the co-injection of lipoplexes bearing herpes simplex virus thymidine kinase and canine interferon-β genes at the time of surgery, combined with the periodic administration of a subcutaneous genetic vaccine composed of tumor extracts and lipoplexes carrying the genes of human interleukin-2 and human granulocyte-macrophage colony-stimulating factor. Following complete surgery (CS), the combined treatment (CT) significantly raised the portion of local disease-free canine patients from 11% to 83% and distant metastases-free (M0) from 44% to 89%, as compared with surgery-only-treated controls (ST). Even after partial surgery (PS), CT better controlled the systemic disease (M0: 82%) than ST (M0: 48%). Moreover, compared with ST, CT caused a significant 7-fold (CS) and 4-fold (PS) rise of overall survival, and >17-fold (CS) and >13-fold (PS) rise of metastasis-free survival. The dramatic increase of PS metastasis-free survival (>1321 days) and CS recurrence- and metastasis-free survival (both >2251 da...Continue Reading

References

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Mar 25, 2010·BMJ : British Medical Journal·David MoherDouglas G Altman
Feb 9, 2011·Research in Veterinary Science·Liliana M E FinocchiaroGerardo C Glikin
Nov 6, 2012·Trends in Immunology·Mercedes B FuertesThomas F Gajewski
Oct 17, 2013·Pigment Cell & Melanoma Research·R Mark SimpsonStephen M Hewitt
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Dec 17, 2014·TheScientificWorldJournal·Gerardo Claudio Glikin, Liliana María Elena Finocchiaro

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Citations

Sep 12, 2015·The Journal of Pathology·Louise van der WeydenDavid J Adams
Oct 25, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Chiara FondelloLiliana M E Finocchiaro
Jun 8, 2017·World Journal of Experimental Medicine·Liliana M E Finocchiaro, Gerardo C Glikin
Nov 27, 2018·ILAR Journal·Nana H OvergaardGregers Jungersen
Jun 22, 2019·Cancer Immunology, Immunotherapy : CII·Lidia TaroneFederica Riccardo
Jan 7, 2017·Oncotarget·Huafeng WangLinjing Zhang
Aug 8, 2018·Veterinary Sciences·Liliana M E FinocchiaroGerardo C Glikin
Dec 6, 2019·Frontiers in Oncology·Douglas H Thamm
Jul 5, 2018·Diseases·Chiaki Hidai, Hisataka Kitano
Feb 15, 2019·Veterinary Sciences·Ramón M Almela, Agustina Ansón

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Methods Mentioned

BETA
Assay

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