Cytokine enhancement of immunogenicity in chronic myeloid leukaemia

Leukemia
S ColemanS H Lim

Abstract

Various clinical and laboratory observations suggest that the leukaemia cells in chronic myeloid leukaemia (CML) are potentially immunogenic. Whilst the ability of the leukaemia cells to elicit an anti-leukaemic immune response in the allogeneic setting is established, it remains unclear why such anti-leukaemic response does not occur in vivo in the autologous setting. We previously demonstrated the presence of leukaemia-reactive T cells in a patient with CML. However, we found that the T cells were normally anergic unless pre-incubated in vitro in high-dose recombinant interleukin-2. We speculated that the T cell anergy was the result of a lack of the appropriate immune costimulatory molecules on the leukaemia cell surface. In this study, we confirm the absence of immune costimulatory molecules, CD80 (B7-1) and CD86 (B7-2), on leukaemia cells and demonstrated that these costimulatory molecules on the leukaemia cells can be upregulated by a combination of GM-CSF and IL-4. There was an associated restoration of leukaemia cell immunogenicity to autologous T cells in mixed lymphocyte leukaemia reactions, suggesting a possible enhancement of anti-leukaemic reaction. More importantly, T cells primed with 'activated' leukaemia cells ...Continue Reading

Citations

Sep 2, 1999·International Journal of Cancer. Journal International Du Cancer·S H Lim, R Bailey-Wood
Dec 25, 2003·Leukemia & Lymphoma·E R KaminskiA G Prentice
Mar 26, 2003·Cancer·Edmund K Waller, Marc S Ernstoff
Dec 10, 1999·British Journal of Cancer·S H LimL Robinson

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