Cytokine expression, glucocorticoid and growth hormone changes after porcine reproductive and respiratory syndrome virus (PRRSV-1) infection in vaccinated and unvaccinated naturally exposed pigs

Comparative Immunology, Microbiology and Infectious Diseases
Paolo BorghettiPaolo Martelli

Abstract

The objective of this paper was to study the changes of some cytokines and neuroendocrine hormones in vaccinated and unvaccinated pigs that were naturally infected by a PRRSV-1 (porcine reproductive and respiratory syndrome virus) heterologous field strain. We analyzed gene expression of pro-inflammatory (TNF-α, IL-1β, MCP-1, IL-6), pro-immune (IFN-γ) and anti-inflammatory cytokines (IL-10) in PBMC, as well as hormonal (GH and cortisol) levels in blood samples of pigs obtained in a field trial previously reported [Martelli P, Gozio S, Ferrari L, Rosina S, De Angelis E, Quintavalla C, et al. Efficacy of a modified-live porcine reproductive and respiratory syndrome virus (PRRSV) vaccine in pigs naturally exposed to a heterologous European (Italian cluster) field strain: clinical protection and cell-mediated immunity. Vaccine 2009;27:3788-99]. All vaccinated pigs showed an increase in pro-inflammatory and pro-immune cytokine gene expression with respect to controls and a prompt increase in GH that could be consistently associated with pro-inflammatory cytokines in sustaining innate immunity; moreover, the higher levels of cortisol indicates the activation of the hypothalamus-pituitary-adrenal (HPA) axis response. In contrast, unva...Continue Reading

Citations

Dec 14, 2011·Animal Health Research Reviews·Yongming SangFrank Blecha
May 9, 2012·Animal : an International Journal of Animal Bioscience·P SuperchiA Sabbioni
Mar 1, 2014·Animal : an International Journal of Animal Bioscience·M J SlifierzA Farzan
Aug 16, 2011·Experimental Physiology·Rick Sai-Chuen WuChieh-Hsi Wu
Jan 1, 2014·Frontiers in Veterinary Science·Massimo Amadori, Elisabetta Razzuoli

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