Cytokine expression in peripheral blood lymphocytes before and after aspirin desensitization in aspirin-exacerbated respiratory disease

Allergy and Asthma Proceedings
Goutam P ShomeRonald Kennedy

Abstract

Aspirin intolerance is the hallmark of aspirin-exacerbated respiratory disease (AERD). Overproduction of cysteinyl-leukotrienes (Cys-LTs) has been implicated as major mediators of AERD; however, the LT receptor antagonist montelukast is only partially effective in inhibiting aspirin responses. Several studies have documented the importance of cytokine production by T lymphocytes in asthma. Peripheral blood lymphocyte (PBL) cytokine expression and its relation to aspirin desensitization in aspirin-sensitive patients with asthma have not been studied. This study was performed to examine PBL cytokine expression in aspirin-sensitive patients who have asthma before and after aspirin desensitization. A 42-year-old white woman with a history of severe asthma, nasal polyps, aspirin sensitivity, and chronic sinusitis was treated with aspirin desensitization. Blood was taken before and after aspirin desensitization, and PBL cytokine expression was studied by flow cytometry. Aspirin desensitization differentially affects interferon (IFN) gamma expression. This effect results in an increase in IFN-gamma expression by CD4(+) lymphocytes and a decrease in IFN-gamma expression by CD8(+) lymphocytes. Aspirin desensitization in an aspirin-sensi...Continue Reading

Citations

Dec 19, 2012·Clinical Biochemistry·Arun NarayanankuttyLuis M Teran
Jun 29, 2013·The Journal of Allergy and Clinical Immunology·John W SteinkeLarry Borish
Jun 18, 2015·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Hossein EsmaeilzadehNegar Mortazavi
Oct 8, 2016·Immunology and Allergy Clinics of North America·John W SteinkeLarry Borish
Oct 8, 2016·Immunology and Allergy Clinics of North America·Jennifer HillRohit Katial
Jan 16, 2015·American Journal of Rhinology & Allergy·John W Steinke, Larry Borish
Dec 25, 2008·Current Opinion in Allergy and Clinical Immunology

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