Cytokine gene polymorphism associations with congenital cytomegalovirus infection and sensorineural hearing loss

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
Beata KasztelewiczKatarzyna Dzierżanowska-Fangrat

Abstract

Cytomegalovirus (CMV) is the most common viral agent of congenital infections and a leading nongenetic cause of sensorineural hearing loss (SNHL). The host immunologic factors that render a developing foetus prone to intrauterine CMV infection and development of hearing loss are unknown. The aim of this study was to assess the potential associations between the polymorphisms within cytokine and cytokine receptors genes, and the risk of congenital CMV infection, and the hearing outcome. A panel of 11 candidate single nucleotide polymorphisms (SNPs): TNF rs1799964, TNF rs1800629, TNFRSF1A rs4149570, IL1B rs16944, IL1B rs1143634, IL10 rs1800896, IL10RA rs4252279, IL12B rs3212227, CCL2 rs1024611, CCL2 rs13900, CCR5 rs333 was genotyped in 470 infants (72 with confirmed intrauterine CMV infection and 398 uninfected controls), and related to congenital CMV infection, and the outcome. In multivariate analysis, the IL1B rs16944 TT and TNF rs1799964 TC genotypes were significantly associated with intrauterine CMV infection (aOR = 2.32; 95% CI, 1.11-4.89; p = 0.032, and aOR = 2.17, 95% CI, 1.25-3.77; p = 0.007, respectively). Twenty-two out of 72 congenitally infected newborns had confirmed SNHL. Carriers of CT or TT genotype of CCL2 rs13...Continue Reading

References

Feb 24, 2001·Genes and Immunity·J BidwellS D'Alfonso
May 3, 2001·The New England Journal of Medicine·S B BoppanaW J Britt
Jul 12, 2002·Trends in Microbiology·Edward S Mocarski
Oct 21, 2003·International Journal of Cancer. Journal International Du Cancer·Axel zur HausenAmado Salvador Peña
May 25, 2006·Bioinformatics·Xavier SoléVíctor Moreno
Jun 21, 2007·Reviews in Medical Virology·Aileen Kenneson, Michael J Cannon
Jul 14, 2010·The Journal of Infectious Diseases·Efe SezginUNKNOWN SOCA Research Group
Oct 29, 2011·Acta Neuropathologica·Natacha TeissierHoma Adle-Biassette
Mar 29, 2012·Immunologic Research·Vanessa NoriegaDomenico Tortorella
Dec 7, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David E Soper
Dec 7, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Suresh B BoppanaKaren B Fowler
Dec 7, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Karen B Fowler

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Citations

Aug 10, 2019·Frontiers in Genetics·Efe SezginCheryl A Winkler
Jan 11, 2020·Frontiers in Immunology·K P Sindura, Moinak Banerjee
Sep 1, 2017·Current Opinion in Otolaryngology & Head and Neck Surgery·Allison M Dobbie
Jun 2, 2020·Virus Research·Joel Henrique EllwangerJosé Artur Bogo Chies
May 1, 2021·Ear and Hearing·Bénédicte VosElizabeth M Fitzpatrick

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Methods Mentioned

BETA
genotyping
PCR

Software Mentioned

StatSoft
Statistica
SNPStats

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