Cytokine gene polymorphisms in Turkish patients with inflammatory bowel disease

Scandinavian Journal of Gastroenterology
Yasemin CelikA Mithat Bozdayi

Abstract

Crohn's disease (CD) and ulcerative colitis (UC) are chronic inflammatory diseases of the bowel, the causes of which are not fully known. Ethnic differences in disease prevalence, familial aggregation of the disease and studies of twins provide the most important evidence to suggest that genetic factors play a role in the pathogenesis of inflammatory bowel disease (IBD). The aim of this study was to examine the allelic polymorphisms that can determine the immune response levels in tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1B), interleukin-1 receptor antagonist ( IL-1RN) and interleukin-10 (IL-10) genes and to investigate their roles in the inflammatory pathway in IBD. The study included 120 patients with UC and 70 patients with CD who were diagnosed either endoscopically or histopathologically. The control group comprised 105 healthy individuals who stated that they had never had any bowel disease during their life span. The polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method for polymorphisms in the TNFalpha gene at positions -308 and -238, the IL-10 gene at positions -1082 and -627, the IL-1B gene at -511 regions and the variable number of tandem repeat (VNTR) method for po...Continue Reading

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Citations

Mar 6, 2007·Journal of Periodontology·A Pinar SumerHasan Bagci
Aug 14, 2008·World Journal of Gastroenterology : WJG·Lynnette R FergusonDug Yeo Han
Aug 1, 2009·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Vito D CorletoGianfranco Delle Fave
Apr 28, 2009·International Journal of Immunogenetics·K-S LiD-W Mao
May 12, 2010·Alimentary Pharmacology & Therapeutics·Z HanD Fan
Oct 30, 2007·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·T MolnarUNKNOWN Hungarian IBD Study Group
Sep 3, 2011·Inflammatory Bowel Diseases·Siew C NgJoseph J Y Sung
Jul 15, 2009·Genetic Testing and Molecular Biomarkers·Rami A R MahfouzAli Bazarbachi
Dec 4, 2014·Digestive Diseases and Sciences·Nasser Ebrahimi DaryaniNima Rezaei
Sep 6, 2017·Immunological Investigations·Nasser Ebrahimi DaryaniNima Rezaei
Jun 24, 2008·Scandinavian Journal of Gastroenterology·Andrea TeddeLaura Papi

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