Cytokine IL-1 beta but not IL-1 alpha promoter polymorphism is associated with Alzheimer disease in a population from the Canary Islands, Spain

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
M C Déniz-NaranjoF Sánchez-García

Abstract

Previous studies have reported the presence of low-grade inflammation in Alzheimer disease (AD). Based on these data, our work attempts to investigate the effects of some promoter polymorphisms of pro-inflammatory cytokines [interleukin (IL)-1 alpha and IL-1 beta] on AD. A PCR-RFLP technique was used to analyze the promoter polymorphisms of both IL-1 alpha (-889 C/T) and IL-1 beta (-511 C/T) and the APOE genotype from the DNA samples of 282 patients (according to NINCDS-ADRDA criteria) and 312 control subjects. (i) The risk of developing AD in our population was associated with the IL-1 beta (-511 C/T) promoter polymorphism; (ii) such risk was independent of the risk factor allele in the APOE gene (APOE4); and (iii) the IL-1 alpha promoter polymorphism (-889 C/T) was not associated with the disease. In our population, IL-1 beta promoter polymorphism (-511 C/T) is an independent risk factor for AD.

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Citations

Jun 4, 2011·Genetics and Molecular Biology·Alex Augusto VendraminiSpencer Luiz Marques Payão
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Nov 16, 2019·CNS Neuroscience & Therapeutics·Meng-Yan HuWei Cai

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