PMID: 8941970Sep 1, 1996Paper

Cytokine-induced inflammation in the ovine teat and udder

Veterinary Immunology and Immunopathology
K PerssonH F Seow

Abstract

The inflammatory response, as measured by the accumulation of leukocytes and ovine serum albumin, induced by interleukin-1 beta (IL-1 beta), tumour necrosis factor-alpha (TNF-alpha), interleukin-beta (IL-8), and granulocyte-macrophage colony stimulating factor (GM-CSF) was studied in lactating ovine udders, and in test cisterns of dry ewes after surgical closure of the passage between the teat and udder cisterns. In the lactating udders, IL-1 beta and TNF-alpha, but not IL-8 and GM-CSF, induced significant accumulation of cells. In the teat cisterns, all four cytokines IL-1 beta, TNF-alpha, IL-8, and GM-CSF induced significant cell accumulation. IL-1 beta was the most potent cytokine. A slight increase in serum albumin, paralleling the changes in leukocyte numbers, was observed after infusion of IL-1 beta and, to some extent, TNF-alpha. The cell accumulation induced by IL-1 beta or TNF-alpha was dose and time dependent in lactating udders, and time-dependent in teat cisterns. The cell numbers were considerably higher in lactating udders than in teat cisterns after infusion with IL-1 beta. The first influx of cells was observed earlier, and the cell numbers peaked earlier in the teat cisterns than in the lactating udders. IL-8 a...Continue Reading

References

Aug 1, 1990·Journal of Leukocyte Biology·I G ColditzM Baggiolini
Oct 1, 1989·The Journal of Clinical Investigation·M BaggioliniS L Kunkel
Sep 1, 1989·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·K Persson, G Aström
Oct 1, 1988·Inflammation·I G Colditz, B L Presson
Feb 1, 1995·Veterinary Immunology and Immunopathology·H F SeowP R Wood
Oct 1, 1994·Immunology and Cell Biology·H F SeowI G Colditz
Jun 1, 1994·Veterinary Immunology and Immunopathology·H F SeowP R Wood
Jul 1, 1993·Veterinary Immunology and Immunopathology·K PerssonC Hallén Sandgren
Mar 1, 1993·Journal of Leukocyte Biology·K Mulder, I G Colditz
Mar 1, 1996·Veterinary Immunology and Immunopathology·G EntricanD M Haig

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Citations

Dec 25, 2003·Journal of Comparative Pathology·V S MavrogianniI A Taitzoglou
Mar 14, 2001·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·A WatanabeY Yokomizo
May 31, 2007·Anatomia, histologia, embryologia·V S MavrogianniG C Fthenakis

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