Cytokine-induced monocyte characteristics in SLE.

Journal of Biomedicine & Biotechnology
Zhe ZhangKathleen E Sullivan

Abstract

Monocytes in SLE have been described as having aberrant behavior in a number of assays. We examined gene expression and used a genome-wide approach to study the posttranslational histone mark, H4 acetylation, to examine epigenetic changes in SLE monocytes. We compared SLE monocyte gene expression and H4 acetylation with three types of cytokine-treated monocytes to understand which cytokine effects predominated in SLE monocytes. We found that gamma-interferon and alpha-interferon both replicated a broad range of the gene expression changes seen in SLE monocytes. H4 acetylation in SLE monocytes was overall higher than in controls and there was less correlation of H4ac with cytokine-treated cells than when gene expression was compared. A set of chemokine genes had downregulated expression and H4ac. Therefore, there are significant clusters of aberrantly expressed genes in SLE which are strongly associated with altered H4ac, suggesting that these cells have experienced durable changes to their epigenome.

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Citations

Sep 24, 2011·Clinical & Developmental Immunology·Chary López-PedreraMa José Cuadrado
Feb 20, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Zijun WangZhihui Wang
May 2, 2019·Frontiers in Immunology·Chary Lopez-PedreraCarlos Perez-Sanchez
Mar 9, 2018·Frontiers in Immunology·Rob J W ArtsMihai G Netea
Oct 8, 2015·Epigenomics·Lihua ShiKathleen E Sullivan

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Datasets Mentioned

BETA
GSE10325

Methods Mentioned

BETA
flow cytometry
acetylation
ChIP-chip
immunoprecipitation

Software Mentioned

UCSC Genome Browser
DAVID

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