PMID: 8589669Oct 1, 1995Paper

Cytokine-inducing glycolipids in the lipoteichoic acid fraction from Enterococcus hirae ATCC 9790

FEMS Immunology and Medical Microbiology
Y SudaShoichi Kusumoto

Abstract

Five high molecular weight glycolipids capable of stimulating human peripheral whole-blood cell cultures to cause interleukin 6 (IL-6) and tumor necrosis factor (TNF)-alpha induction were isolated from one of the lipoteichoic acid fractions (LTA-2) extracted from Enterococcus hirae ATCC 9790 (Tsutsui et al., (1991) FEMS Microbiol. Immunol. 76, 211-218) by a combination of hydrophobic interaction and anion-exchange chromatographies. This purification procedure resulted in a remarkable increase in the cytokine-inducing activities on the weight basis of isolated glycolipids (a maximum of 36- and 17-fold increases of IL-6 and TNF-alpha induction, respectively). The total yield of these bioactive glycolipids amounted to 6 wt% of the parent LTA-2 fraction, while the recovery rate in terms of the cytokine-inducing activities was estimated to be sufficient. The chemical composition and the profile, using SDS-PAGE, revealed that all of the isolated bioactive components were high molecular weight glycolipids, which were distinct from each other and from the parent LTA-2 fraction. These findings suggest that the IL-6 and TNF-alpha-inducing activities previously noted in the parent LTA-2 fraction are not attributable to a chemical entity, ...Continue Reading

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Citations

Feb 7, 2001·The Journal of Experimental Medicine·S MorathT Hartung
Jun 19, 2002·The Journal of Experimental Medicine·Siegfried MorathThomas Hartung
Jan 18, 2002·Infection and Immunity·Siegfried MorathThomas Hartung
Dec 11, 2003·Microbiology and Molecular Biology Reviews : MMBR·Francis C Neuhaus, James Baddiley
Feb 7, 2007·Infection and Immunity·Masahito HashimotoYasuo Suda
Feb 17, 2009·The Journal of Biological Chemistry·Kazuki TawaratsumidaMasahito Hashimoto
Feb 10, 2000·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·E M EddsK R Brittian
Feb 8, 2006·The Journal of Allergy and Clinical Immunology·Leena von Hertzen, Tari Haahtela
Jun 28, 2013·Organic & Biomolecular Chemistry·Yukari FujimotoKoichi Fukase
Oct 25, 2007·Journal of Endotoxin Research·Corinna Hermann
Jun 18, 2017·Medicinal Research Reviews·Jian Gao, Zhongwu Guo
Aug 15, 2017·Journal of Veterinary Pharmacology and Therapeutics·J R BauquierS R Bailey
Dec 24, 2005·International Immunology·Masahito HashimotoYasuo Suda
Aug 22, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Masahito HashimotoFriedrich Götz
Apr 17, 2001·Angewandte Chemie·Hiroaki YoshizakiShoichi Kusumoto

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