Cytokine induction of prolactin receptors mediates prolactin inhibition of nitric oxide synthesis in pulmonary fibroblasts

FEBS Letters
A M CorbachoC Clapp

Abstract

Prolactin (PRL) has been implicated as a modulator of immune function, and some of its actions may be linked to NO synthesis. Because NO acts as a mediator of inflammation, we speculated that an inflammatory milieu could unmask pathways by which PRL could affect NO synthesis. Here, we show that pro-inflammatory cytokines induce the expression of PRL receptors in pulmonary fibroblasts, allowing PRL to inhibit cytokine-induced NO production and the expression of the inducible nitric oxide synthase (iNOS). Inhibition of iNOS expression by PRL correlates with the phosphorylation of STAT-5b (signal transducer and activator of transcription 5b) and the suppression of expression of IRF-1 (interferon regulatory factor 1), a transcription factor for iNOS. These results reveal previously unrecognized mechanisms by which PRL and PRL receptors may play significant modulatory roles during immune-inflammatory processes.

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Citations

Jun 6, 2009·Cancer Research·Vera V LevinaAnna E Lokshin
Aug 3, 2013·The Journal of Clinical Investigation·Norma AdánCarmen Clapp
Jun 5, 2013·Journal of Inflammation·Gonzalo López-RincónCiro Estrada-Chávez
Apr 29, 2014·Psychoneuroendocrinology·Miriam ZamoranoCarmen Clapp
Mar 2, 2006·Pituitary·C GaunaA J van der Lely
Mar 7, 2012·World Journal of Surgery·Yao-Tsung YehShen-Nien Wang
Sep 4, 2007·Trends in Endocrinology and Metabolism : TEM·Carmen ClappGonzalo Martínez de la Escalera
Mar 31, 2016·Cellular and Molecular Life Sciences : CMLS·Carmen ClappGonzalo Martínez de la Escalera
Oct 15, 2013·Comparative Immunology, Microbiology and Infectious Diseases·Gonzalo López-RincónCiro Estrada-Chávez
Mar 9, 2005·Laboratory Investigation; a Journal of Technical Methods and Pathology·Pável Montes de OcaCarmen Clapp
Oct 15, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Claudia VegaCarmen Clapp
Jun 10, 2004·American Journal of Physiology. Endocrinology and Metabolism·Ana M CorbachoCarroll E Cross
Apr 29, 2020·Laboratory Investigation; a Journal of Technical Methods and Pathology·Georgina OrtizCarmen Clapp
Jun 24, 2017·Journal of Leukocyte Biology·Man Wai TangKris A Reedquist
Mar 5, 2021·Reviews in the Neurosciences·Edgar Ramos-MartinezMarco Cerbon
Jul 11, 2021·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Cassandra A HathawayShelley S Tworoger

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