PMID: 8597363Dec 29, 1995Paper

Cytokine inhibitors and graft-versus-host disease

Annals of the New York Academy of Sciences
J L Ferrara

Abstract

Graft-versus-host disease (GVHD) remains the major complication of allogeneic bone marrow transplantation. T cells in donor bone marrow recognize and react to host alloantigens and thereby initiate GVHD, but the precise mechanisms by which host tissues are damaged remain unclear. Recently, several convergent lines of evidence suggested that inflammatory cytokines act as mediators of acute GVHD. Most of the clinical manifestations of GVHD may, in fact, be due to the dysregulated production of cytokines by T cells and other inflammatory cells. The complex interactions among cytokines and their cellular targets suggest that individual cytokines may play an important and distinctive role in the pathophysiology of GVHD. Perturbation of the cytokine network may function as a final common pathway of target organ damage, and the rapid onset of severe, acute GVHD can be considered a "cytokine storm."

References

Jul 1, 1992·The Journal of Experimental Medicine·A K NusslerR L Simmons
Aug 1, 1992·The Journal of Clinical Investigation·J M LangrehrR A Hoffman
Jun 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·A B Troutt, A Kelso
Aug 1, 1992·European Journal of Immunology·P GarsideA M Mowat
Sep 13, 1990·The New England Journal of Medicine·K M SullivanR P Witherspoon
Dec 1, 1987·British Journal of Haematology·R P GaleJ H Kersey
Jan 1, 1993·Leukemia & Lymphoma·S C GulatiC Van Poznak
Feb 1, 1993·European Journal of Immunology·R D AllenC L Sidman
May 1, 1993·Molecular Immunology·C G GarlisiS P Umland

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Citations

Oct 26, 1999·Critical Reviews in Oncology/hematology·G K LauR Liang
Nov 3, 1998·Transplantation·L M LiemE Goulmy
Feb 8, 2005·The Journal of Clinical Investigation·Yang WangYang-Xin Fu
Mar 8, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A NaglerY Ilan
Aug 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R LiangY L Kwong
Jan 16, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Xin Shelley WangCharles S Cleeland
Aug 28, 2021·Cells·Konradin F MüskensMirjam E Belderbos

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