PMID: 9529057Apr 7, 1998Paper

Cytokine involvement in immunomodulatory activity affected by Candida albicans mannan

Infection and Immunity
Y WangJ E Domer

Abstract

Candida albicans mannoprotein (MAN) administered intravenously to mice stimulates the production of splenic CD8+ effector cells which downregulate delayed hypersensitivity (DH) in immunized mice. Cytokine involvement in the induction and/or elicitation of downregulation was studied by (i) examining murine splenocytes qualitatively for mRNA for interleukin-2 (IL-2), IL-4, IL-10, IL-12p40, and gamma interferon (IFN-gamma), (ii) quantitating splenocyte mRNA for IL-12p40 by quantitative-competitive reverse transcriptase-mediated PCR, and (iii) measuring serum levels of IL-12p40 and IL-12p70 by capture enzyme-linked immunosorbent assay, each performed at selected intervals over 96 h after giving MAN. Further, the effect of in vivo administration of anti-IL-4 on the induction and elicitation of MAN-specific DH in MAN-treated mice was measured. Expression of IL-12p40 mRNA in the spleen was reduced to near 0 during the first 24 h but rebounded thereafter. Transcripts for IL-10 were present throughout the 96-h period, whereas those for IL-4 and IFN-gamma were either weak or undetectable prior to 24 to 48 h. In vivo administration of anti-IL-4 partially abrogated the downregulatory effect of MAN only when given at the time of MAN adminis...Continue Reading

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Citations

Aug 5, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·R Gomez-Flores, R J Weber
May 1, 2020·Frontiers in Chemistry·Shuyao Lang, Xuefei Huang
May 13, 2010·Biological & Pharmaceutical Bulletin·Nobuyuki Shibata, Yoshio Okawa
Apr 22, 2005·The Journal of Biological Chemistry·Steven BatesNeil A R Gow
Dec 20, 2000·Antimicrobial Agents and Chemotherapy·A L BaltchL H Bopp
Nov 3, 2005·The Journal of Biological Chemistry·Steven BatesNeil A R Gow
Mar 8, 2003·Molecular Microbiology·Jonathan D CroweNuala A Booth
Dec 17, 2008·Future Microbiology·Rosalía Diez-Orejas, Elena Fernández-Arenas

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