Cytokine Levels and Human Herpesviruses in Saliva from Clinical Periodontal Healthy Subjects with Peri-Implantitis: A Case-Control Study

Mediators of Inflammation
Jaime S Marques FilhoDebora Pallos

Abstract

This study evaluated the presence of cytokines (IL-1β, IL-2, IL-4, IL-6, MCP-1, MIP-1α, MIP-1β, and TNF-α) and human herpesvirus (HSV1, HSV2, EBV, CMV, VZV, HHV6, HHV7, and HHV8) in saliva samples taken from subjects with and without peri-implantitis. Forty-two periodontally healthy subjects were divided according to peri-implant condition: healthy and peri-implantitis groups. The clinical parameters as probing depth, clinical attachment level, plaque index, gingival bleeding, bleeding on probing, and suppuration were evaluated. For cytokine detection, multiplex analysis was performed, and PCR assay was used to identify herpesviruses. No significant differences were found in cytokine levels between groups (p > 0.05). The presence of herpesvirus was 1.97-fold higher in patients with peri-implantitis (odds ratio, CI 0.52-7.49). The association of the presence or absence of herpesvirus with the salivary markers was statistically significant for MIP-1β (p = 0.0087) and TNF-α (p = 0.0437) only in the peri-implantitis group. The presence of herpesviruses in patients with peri-implantitis suggests the development of a proinflammatory environment, which is characterized by increased expression of MIP-1β and TNF-α in saliva.

References

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Citations

Mar 21, 2020·Medicine·Andreia La SelvaAnna Carolina Ratto Tempestini Horliana
May 10, 2020·Periodontology 2000·Angela R KamerMony J de Leon
Oct 22, 2020·Oral Diseases·Andre L F CostaPaulo H Braz-Silva
Feb 11, 2021·Viruses·Elisabet Roca-MillanJosé López-López
Nov 26, 2020·Brazilian Oral Research·Catielma Nascimento SantosMarcelo Bönecker
Dec 3, 2021·Reviews in Medical Virology·Pari ThakkarAfsar R Naqvi

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Methods Mentioned

BETA
PCR

Software Mentioned

GraphPad Biostat Prism

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