Cytokine levels in cystic renal masses associated with renal cell carcinoma

The Journal of Urology
M HayakawaH Nakamura

Abstract

We compared cytokine levels in fluid from renal cysts with and without renal cell carcinoma. Fluid was aspirated from 18 renal cysts without (benign) and 21 with renal cell carcinoma (malignant). Serum from patients with renal cell carcinoma and healthy controls was collected and cytokines were measured by enzyme-linked immunosorbent assay. Interleukin-6 (IL-6) and basic fibroblast growth factor concentrations were higher in malignant than benign cysts or serum (p <0.006). Epidermal growth factor levels were significantly higher in malignant cysts and serum than in benign cysts (p <0.01). IL-6 levels in malignant cysts positively correlated with the erythrocyte sedimentation rate (R=0.80) and C-reactive protein (R=0.86), and they were higher in grade 3 than in grade 2 tumors. Basic fibroblast growth factor levels were significantly higher in malignant cysts associated with hypervascular than hypovascular tumors (p=0.029). Cytokine levels in aspirated fluid may help to identify malignant renal cysts and indicate the characteristics of coexisting tumors.

References

Dec 1, 1992·The Journal of Urology·T TsukamotoM Yanase
Mar 31, 1992·Biochemical and Biophysical Research Communications·J EguchiY Saito
Jan 1, 1992·Cancer Immunology, Immunotherapy : CII·A S KooA Belldegrum
Jan 23, 1987·Science·J Folkman, M Klagsbrun
Jan 1, 1987·Nouvelle Revue Française D'hématologie·A Camez, G Tobelem
Oct 1, 1971·Radiology·E K Lang
Oct 1, 1982·British Journal of Urology·H KleistS Pettersson
Sep 1, 1993·Kidney International·J GogusevD Droz
Feb 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J J Grantham
Oct 6, 1993·Journal of the National Cancer Institute·D M NanusV E Reuter
Sep 1, 1996·International Journal of Urology : Official Journal of the Japanese Urological Association·T AoyagiH Nakamura
Dec 1, 1963·British Journal of Urology·J L EMMETTL B WOOLNER

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Citations

Oct 26, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·T RasmusonB Ljungberg
Apr 10, 2009·Kidney International·Angel A Soler-GarcíaPatricio E Ray
Apr 30, 2003·Advances in Anatomic Pathology·Luan D TruongBhuvaneswari Krishnan
Jun 7, 2002·The Journal of Urology·Hiroshi HaradaTakashi Yoshiki

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