PMID: 7544549Sep 1, 1994Paper

Cytokine modulation of basophil histamine release in wasp-venom allergy

Allergy
M F RadermeckerT Bury

Abstract

We report the effect of interleukin-3 (IL-3) and of other cytokines on antigen-induced basophil histamine release in wasp-venom-allergic subjects. Leukocytes from 12 patients with documented anaphylactic sensitivity to wasp venom were preincubated in the presence or absence of IL-3, granulocyte/macrophage-colony stimulating factor (GM-CSF), IL-5, IL-8, or stem cell factor (SCF). Washed cells were then exposed to venom and to other secretagogues, and histamine release in the supernatant was measured fluorometrically. Preincubation of leukocytes with IL-3, GM-CSF, or IL-5 (0.02-2 ng/ml), but not with IL-8 and SCF, caused a dose-dependent enhancement of antigen-induced basophilic histamine release in all subjects tested. Mean maximum increase was about 100% for IL-3, IL-5, and GM-CSF. The priming effect of IL-3 was rapid, persisted up to 12 h, and was not accompanied by a change in cellular histamine. IL-3 had a comparable enhancing effect when basophils were triggered with anti-IgE or N-formylmethionylphenylalanine (FMP). By contrast, IL-3 had no effect on substance-P-induced histamine release. The significant enhancement of basophil releasability to antigen in wasp-venom allergy by very low concentrations of IL-3, GM-CSF, and IL...Continue Reading

References

Jul 27, 1978·The New England Journal of Medicine·K J HuntL M Lichtenstein
Jul 1, 1979·The Journal of Allergy and Clinical Immunology·L M LichtensteinA K Sobotka
Jan 1, 1992·The Journal of Experimental Medicine·S C Bischoff, C A Dahinden
Jan 1, 1990·International Archives of Allergy and Applied Immunology·R E Louis, M F Radermecker
Jan 1, 1990·International Archives of Allergy and Applied Immunology·R D MergetJ Meier-Sydow
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·P ValentP Bettelheim
Aug 1, 1989·The Journal of Experimental Medicine·Y KurimotoC A Dahinden
May 1, 1985·The Journal of Allergy and Clinical Immunology·R E Reisman
Feb 1, 1982·The Journal of Allergy and Clinical Immunology·J L ParkerJ W Yunginger

❮ Previous
Next ❯

Citations

Apr 24, 2004·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Antonella CianferoniAlberto Vierucci
Sep 22, 2009·The Journal of Allergy and Clinical Immunology·Shelley F StoneUNKNOWN Emergency Department Anaphylaxis Investigators
Jan 26, 1999·Movement Disorders : Official Journal of the Movement Disorder Society·N A LeopoldM Hallett

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basophils

Basophils are myeloid cells with a high affinity IgE receptor and is involved in inflammatory responses during allergy. Discover the latest research on Basophils here.

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.

Related Papers

Journal of Medical Entomology
Lee S FriedmanDaniel Hryhorczuk
Indian Journal of Pediatrics
R Rathi SharmilaS Srinivasan
British Medical Journal
A N Gale
International Archives of Allergy and Applied Immunology
H G NüssleinJ R Kalden
Journal of Neurology, Neurosurgery, and Psychiatry
J GállegoJ A Villanueva
© 2021 Meta ULC. All rights reserved