PMID: 9525456Apr 3, 1998Paper

Cytokine mRNA expression in asthma is not restricted to the large airways

The Journal of Allergy and Clinical Immunology
E M MinshallQ Hamid

Abstract

Although previous studies have established the presence of an eosinophil-rich cellular infiltrate in the small airways of asthmatic lungs, the expression of cytokines within the peripheral airways has been largely unexplored. The purpose of our study was to test the hypothesis that TH2-type cytokines are increased in the peripheral airways and parenchyma of asthmatic lungs. The presence of messenger ribonucleic acid (mRNA) encoding both T-helper (TH1)-type (IL-2, interferon-gamma) and TH2-type (IL-4, IL-5) cytokines in surgically resected lungs from six asthmatic and 10 nonasthmatic subjects was determined by in situ hybridization. Colocalization of IL-5 mRNA within the large and small airways was performed by simultaneous in situ hybridization and immunocytochemistry. Expression of IL-5 mRNA-positive cells was significantly increased in the large and small airways and in the lung parenchyma of asthmatic subjects compared with nonasthmatic subjects. In the asthmatic individuals, the expression of IL-5 mRNA was increased in the small airways compared with the large airways. There was also an increase in the number of cells expressing IL-4 mRNA in the large and small asthmatic airways compared with the nonasthmatic airways. In co...Continue Reading

Citations

Oct 23, 2008·Current Allergy and Asthma Reports·Jonathan Corren
Nov 25, 2003·Paediatric Respiratory Reviews·Sally Wenzel
Feb 17, 2005·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Philippe H Jais
Jul 7, 2009·Annual Review of Physiology·Qutayba Hamid, Meri Tulic
Sep 16, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Prerna RastogiJane McHowat
Oct 6, 1999·American Journal of Respiratory and Critical Care Medicine·K GrünbergP J Sterk
Nov 26, 2004·American Journal of Respiratory and Critical Care Medicine·Silvana BalzarSally Wenzel
Dec 31, 1998·American Journal of Respiratory Cell and Molecular Biology·D S RobinsonQ Hamid
Jun 6, 2009·Clinical Pharmacokinetics·Rüdiger Nave
Jan 1, 2007·Annals of Thoracic Medicine·Qutayba Hamid, Meri K Tulic
Nov 4, 2000·Expert Opinion on Investigational Drugs·J K Weltman, A S Karim
Mar 12, 2003·Chest·Sally Wenzel
Mar 18, 2006·Clinics in Chest Medicine·Sally Wenzel
Dec 18, 2012·Respirology : Official Journal of the Asian Pacific Society of Respirology·Tomoyuki FujisawaKingo Chida
Jul 19, 2012·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M ContoliA Papi
Nov 9, 2005·The Journal of Allergy and Clinical Immunology·Celine BergeronQutayba Hamid
Jul 25, 2000·Clinics in Chest Medicine·S MuroQ A Hamid
May 30, 2013·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Xun ChenGuang-Min Nong
Apr 7, 2007·Journal of Clinical Pharmacology·Hartmut Derendorf
Mar 17, 2015·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C VockM Wegmann
Jun 20, 2012·International Immunopharmacology·Fausto K FerrarisMaria das Graças M O Henriques
Jul 24, 2013·Respiratory Physiology & Neurobiology·Marcos C BorgesMara S Ludwig
Jul 26, 2014·Clinical Science·Anders BergqvistJonas S Erjefält
Oct 10, 2007·Current Medical Research and Opinion·Jill P Karpel, Harold Nelson
Oct 20, 2007·Current Medical Research and Opinion·Monica Kraft
Jan 28, 2015·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Jordis TrischlerChristiane Lex
Jun 15, 2013·Respiratory Medicine·K Konstantinos KatsoulisTheodore Kontakiotis
Mar 9, 1999·The Journal of Allergy and Clinical Immunology·R A TahaQ A Hamid
Apr 2, 2016·American Journal of Respiratory Cell and Molecular Biology·Sidra M HoffmanYvonne M W Janssen-Heininger
Jan 9, 2010·The Journal of Allergy and Clinical Immunology·Dallas M HydeCharles G Irvin
Jan 4, 2017·PloS One·Akul SinghaniaPeter H Howarth
Feb 3, 2011·Chest·Maarten van den BergeDirkje S Postma
Dec 6, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S Wenzel
Jul 5, 2012·Respiration; International Review of Thoracic Diseases·Qutayba Hamid
Nov 14, 2018·Current Opinion in Pulmonary Medicine·Jonas S Erjefält
Jul 13, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L A MillerD M Hyde
Sep 2, 2015·European Respiratory Review : an Official Journal of the European Respiratory Society·Daniel DobererSally E Wenzel
Oct 22, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M WegmannH Renz
Jan 3, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Laura PiniMara S Ludwig
Jan 24, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Stéphane Lajoie-KadochQutayba Hamid

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