PMID: 8590302Nov 1, 1995Paper

Cytokine mRNA expression patterns in human esophageal cancer cell lines

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
M OkaT Suzuki

Abstract

The mRNA expression for 21 kinds of cytokines was measured in six human esophageal cancer cell lines using RT-PCR. More than moderate levels of RNA for IL-1 alpha were expressed in six of six cell lines, IL-1 beta in four, IL-6 in six, IL-7 in five, IL-10 in six, G-CSF in six, GM-CSF in six, SCF in six, MIP-2 beta in two, and LIF in six. None of the tumors expressed detectable message for IL-2, 3, 4, 5, 8, 11, 13, or IRAP after 30 cycles of PCR amplification. IL-1 alpha, IL-6, M-CSF, and GM-CSF levels in the culture supernatants were detectable using ELISA in three of six, four of six, one of six, and six of six ECCs, respectively. IL-1 beta, IL-2, TNF-alpha, and G-CSF were not detectable in all ECCs. There was no correlation between cytokine mRNA expression and production. These results suggest the existence of a complicated cytokine network around esophageal carcinomas that may affect their growth and proliferation.

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Citations

Jan 21, 2000·Hematological Oncology·J W HoG Srivastava
Oct 16, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Giang Huong NguyenCurtis C Harris
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