Cytokine overproduction in healthy first degree relatives of patients with IDDM

Diabetologia
M J HussainD Vergani

Abstract

Healthy family members of patients with insulin-dependent diabetes mellitus (IDDM) are known to share a number of immunological abnormalities with their affected relatives. Since monocyte and type 1 T-cell-derived cytokines contribute to the pathogenesis of IDDM, we studied the production of these cytokines in the healthy first degree relatives of 29 children with IDDM. We report that circulating tumour necrosis factor-alpha (TNF-alpha) and soluble interleukin-2 (sIL-2) receptor were present in increased amounts in non-diabetic family members at levels similar to those found in the diabetic children (duration of disease 3 months-5 years). Furthermore, marked hypersecretion of IL-1alpha and TNF-alpha by mitogen-stimulated peripheral blood mononuclear cells was found in both diabetic and healthy family members. Abnormalities of cytokine production in healthy relatives did not correlate with the presence of islet cell antibodies or with HLA DR type. These data indicate that healthy family members of patients with IDDM exhibit overproduction of a number of cytokines that have been implicated in diabetogenesis.

Citations

Dec 2, 2004·Nature Reviews. Immunology·Bart O RoepMatthias von Herrath
Sep 16, 2011·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Jennifer Knight-MaddenAnne Greenough
Jul 26, 2006·Mediators of Inflammation·Yasar DoganMetin Kaya Gurgoze
Jan 1, 2012·The Review of Diabetic Studies : RDS·Yulan Jin, Jin-Xiong She
Dec 25, 2015·Diabetologia·Susanne M CabreraMartin J Hessner
May 20, 2015·Translational Research : the Journal of Laboratory and Clinical Medicine·Susanne M CabreraMartin J Hessner
Aug 22, 2012·Human Immunology·Jannet SvenssonUNKNOWN Danish Childhood Diabetes Registry
Jun 15, 2010·Diabetes Research and Clinical Practice·Li Bai-FengCheng Ying
Jun 27, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Charalambos Gustav AntoniadesJulia Wendon
Feb 21, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Fang LinYun Ma
Apr 25, 2014·Diabetes·Yi-Guang ChenMartin J Hessner
Oct 19, 2006·Mediators of Inflammation·Grazyna DejaEwa Małecka-Tendera
Jul 15, 2016·Pediatric Diabetes·Flemming PociotLotte B Nielsen
Oct 21, 2011·Physiological Reviews·Domenico BoscoPaolo Meda
May 15, 2002·Journal of Pediatric Endocrinology & Metabolism : JPEM·Mariapina PomilioFrancesco Chiarelli
Mar 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maria Serena LonghiYun Ma
Sep 15, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elizabeth M BradshawDavid A Hafler

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.