Apr 1, 1993

Cytokine patterns in the pathogenesis of human leishmaniasis

The Journal of Clinical Investigation
Claude PirmezR L Modlin

Abstract

The host response to infection appears to be regulated by specific patterns of local cytokine production. In the mouse, resistance to many pathogens including Leishmania is associated with a TH1 cytokine profile, IL-2 and IFN-gamma; whereas susceptibility to infection is associated with production of TH2 cytokines, IL-4, IL-5, and IL-10. To determine the cytokine patterns of the local immune response to Leishmania infection in humans, we used the polymerase chain reaction to compare cytokine mRNAs in biopsy specimens of American cutaneous leishmaniasis. In localized cutaneous leishmaniasis and the Montenegro delayed-type hypersensitivity reaction, type 1 cytokine mRNAs such as IL-2, IFN-gamma, and lymphotoxin were relatively predominant. In the chronic and destructive mucocutaneous form of leishmaniasis, there was a mixture of type 1 and type 2 cytokines, with a striking abundance of IL-4 mRNA in lesions. These results suggest that clinical course of infection with Leishmania braziliensis in man is associated with specific local patterns of cytokine production.

  • References21
  • Citations191

References

  • References21
  • Citations191

Citations

Mentioned in this Paper

Immune Response
Pathogenic Aspects
IFNG
Pathogenesis
Il4
Genus: Leishmania
Immediate Hypersensitivity
Recombinant Interleukin-10
IL2
Recombinant Interleukin-5

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