PMID: 8950159Nov 1, 1996Paper

Cytokine production after whole body and localized hyperthermia

International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
J HavemanH M Rodermond

Abstract

The levels of TNF, IL-1 and IL-6 in circulating blood female WAG/Ry rats were assessed in relation to treatment with localized hyperthermia of the right hind leg or with whole-body hyperthermia (WBH). After a localized treatment for 30 min at 43 or 44 degrees C no detectable increase in levels of IL-6 or TNF was obtained. Hyperthermia for 30 min at 45 degrees C led to an elevated level of IL-6 of 19.4 +/- 5.2 U/ml above the control level of 24 h after treatment. Levels of IL-1 were never higher than those in control animals that received only anaesthesia. Anaesthesia induced a peak level of approximately 131 U/ml IL-1 6 h after treatment. Serum levels of IL-1 and IL-6 are enhanced after WBH. IL-1 reaches a peak level already during WBH about 15 after reaching 41.5 degrees C. IL-6 levels were not enhanced during WBH but 1 h after WBH a clear peak was observed. Anaesthesia with sham WBH did not lead to enhanced IL-6 levels but enhanced IL-1 levels were clearly detected. We did not detect TNF in any sample after WBH. It is concluded from the present results that IL-6 is not induced by a 'standard' treatment of localized hyperthermia as used in oncotherapy (i.e. 60 min at 43 degrees C) to such a high level locally that this is refl...Continue Reading

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Citations

Jul 27, 2005·Cancer Immunology, Immunotherapy : CII·Qing ChenSharon S Evans
Nov 24, 2005·Epilepsia·Annamaria Vezzani, Tiziana Granata
Oct 4, 2007·Epilepsia·Roland A Bender, Tallie Z Baram
May 17, 2007·Epilepsy Currents·Annamaria Vezzani, Tallie Z Baram
Mar 8, 2014·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Katelin P PattersonShlomo Shinnar
May 1, 1997·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·F d'OleireH I Robins
Feb 7, 2016·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Mark W DewhirstKathleen A Ashcraft
Dec 29, 2004·Annals of Neurology·Celine DubéTallie Z Baram
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Oct 29, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Djordje AtanackovicSusanna Hegewisch-Becker

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