PMID: 8952004Nov 14, 1996Paper

Cytokine production by human thymic epithelial cells: control by the immune recognition of the neurohypophysial self-antigen

Regulatory Peptides
H MartensV Geenen

Abstract

Oxytocin (OT) has been shown to be the dominant peptide of the neurohypophysial family expressed by thymic epithelial and nurse cells (TEC/TNC) in various species. Thymic OT is not secreted but, after translocation of a hybrid neurophysin/MHC class I protein, is integrated within the plasma membrane of TEC, thus allowing its presentation to pre-T cells. In order to further demonstrate that thymic OT behaves like a membrane antigen, we assessed the effect of mAbs to OT on cytokine productions by cultures enriched in human TEC. 75-85% pure TEC cultures were prepared from human thymic fragments. Using immunofluorescence and confocal microscopy, ir-OT, ir-interleukin-1 beta (IL-1 beta), ir-interleukin-6 (IL-6) and ir-leukemia inhibitory factor (LIF) could be detected in these TEC cultures. ir-OT was restricted to TEC, while some ir-IL-6 and ir-LIF were also seen in occasional fibroblasts. In basal conditions, ir-IL-6 and ir-LIF (but not ir-OT and ir-IL-1 beta) were detected in the supernatants of human TEC cultures. MAbs to OT induced a marked increase of ir-IL-6 and ir-LIF secretion in TEC cultures. No significant effect was observed using mAbs against vasopressin, mouse immunoglobulins, or control ascitic fluid controls. These da...Continue Reading

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Citations

Apr 23, 2002·Journal of Virology·Fabienne BrilotDidier Hober
Jun 10, 2003·Annals of the New York Academy of Sciences·Vincent Geenen, Fabienne Brilot
Jun 12, 2003·American Journal of Reproductive Immunology : AJRI·H KojimaH Honjo
Mar 21, 2002·Expert Opinion on Therapeutic Targets·Bela Bodey
Jun 22, 2012·Diabetes Research and Clinical Practice·Vincent Geenen
Jan 15, 2004·Microscopy Research and Technique·Jonas HannestadJosé A Vega
Jul 21, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·D M Villa-VerdeW Savino
Jan 16, 1999·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·N MaggianoF O Ranelletti
Feb 26, 2008·Journal of Medical Virology·Fabienne BrilotDidier Hober
Aug 19, 2000·Endocrine Reviews·W Savino, M Dardenne
Apr 23, 2019·Annals of the New York Academy of Sciences·Vincent GeenenHenri Martens
May 31, 2001·Immunology and Cell Biology·E U BagriacikJ R Klein
May 21, 1999·Journal of Neuroendocrinology·O KechaR Winkler
Mar 28, 2001·Annals of the New York Academy of Sciences·V GeenenO Kecha
Jan 9, 2021·Seminars in Immunopathology·Vincent Geenen

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