Cytokine production by peripheral blood mononuclear cells in recurrent miscarriage

Cytokine
Hadinedoushan HosseinHatmi Nadia

Abstract

It has been postulated that a proportion of recurrent miscarriage (RM) might be due to immune causes. The objective was to determine whether cytokine expression in peripheral blood mononuclear cell is altered in patients with a history of RM. We compared the levels of IL-2, IL-4, IL-10, IL-13, TGFbeta1 and IFNgamma in the supernatant of Phytohemagglutinin stimulated mononuclear cells in 21 women with RM at the time of 3rd or higher abortion (group I), 32 women who were at least 3 months past their 3rd or higher abortion (group II) and 32 pregnant women with no history of abortion (group III). Gestational age was matched between groups I and III. Group I had higher level of IL-2 than group III (P=0.001). Group II showed higher level of IL-2 (P=0.001) and IFNgamma (P=0.015) than group III. The production of IL-10 by mononuclear cells of group III was higher than both group I (P=0.002) and group II (P=0.001). There was no difference in the levels of IL-2, IL-10 and IFNgamma between groups I and II. Also, the levels of IL-4, IL-13, and TGFbeta1 were similar among the groups. The data indicate an elevation of Th1 cytokines in women with RM as compared to normal pregnant women, and IL-10 is an important cytokine in the maintenance of...Continue Reading

References

Jan 1, 1991·Research in Immunology·J E de VriesH Spits
Jul 1, 1990·Journal of Reproduction and Fertility·G ChaouatT G Wegmann
Jan 1, 1995·American Journal of Reproductive Immunology : AJRI·C B CoulamK D Beaman
Mar 1, 1996·Immunology Today·T R Mosmann, S Sad
Nov 14, 1997·Immunology Today·R Raghupathy
Apr 3, 1998·The Journal of Allergy and Clinical Immunology·L Borish
May 20, 2003·Human Reproduction Update·S M LairdT C Li
Jul 19, 2003·Scandinavian Journal of Immunology·B R Lúdvíksson, B Gunnlaugsdóttir
Aug 21, 2003·Human Reproduction Update·A L Veenstra van NieuwenhovenM M Faas

❮ Previous
Next ❯

Citations

Nov 29, 2007·Journal of Assisted Reproduction and Genetics·Gérard ChaouatNathalie Ledée
Jul 10, 2007·Journal of Assisted Reproduction and Genetics·Donald S TorryRonald J Torry
Sep 18, 2014·Journal of Assisted Reproduction and Genetics·Soheil NajafiAbbas Aflatoonian
Feb 19, 2013·Molecular Human Reproduction·K MagdoudR Touraine
Oct 27, 2015·Biological Chemistry·Paola SignorelliAnna Caretti
Jan 24, 2012·Cytokine·Stefano R GiannubiloMonica Emanuelli
Feb 16, 2008·American Journal of Reproductive Immunology : AJRI·Behrouz Gharesi-FardEskandar Kamali-Sarvestani
Apr 7, 2010·American Journal of Reproductive Immunology : AJRI·Julia Szekeres-Bartho, Beata Polgar
Jul 16, 2014·Human Fertility : Journal of the British Fertility Society·Hossein HadinedoushanGilda Eslami
Jun 7, 2014·Frontiers in Immunology·Piyali ChatterjeeBrett M Mitchell
Feb 23, 2019·Immunological Investigations·Fateme RahmaniNasrin Ghasemi
Jan 9, 2019·Frontiers in Immunology·Julia Szekeres-BarthoBiserka Mulac-Jeričević
Aug 28, 2021·International Journal of Environmental Research and Public Health·Maciej KwiatekAnna Kwaśniewska

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.