PMID: 8955579Nov 1, 1996Paper

Cytokine production in children outgrowing hen egg allergy

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
T NomaM Baba

Abstract

Approximately 40 to 80% of egg-allergic children outgrow egg allergy after 2 to 5 years. To detail the immunologic mechanisms involved in the development of tolerance to egg proteins, the balance between interleukin 4 (IL4) and interferon-gamma (IFN-gamma) synthesis in patients with active atopic dermatitis allergic to hen egg and in those outgrowing hen egg allergy was evaluated. A marked increase in IL4 and a decrease in IFN-gamma synthesis by peripheral blood lymphocytes following ovalbumin (OVA) specific in vitro stimulation was observed in active atopic dermatitis. In contrast, OVA-induced IL4 synthesis in patients in remission was comparable to that in normal individuals. An intriguing finding was higher production of IFN-gamma by lymphocytes from ovalbumin-insensitive patients in remission as compared to normal individuals following antigen stimulation, although cell proliferation in OVA-stimulated lymphocytes was reduced in patients during remission. OVA antigen may be capable of inducing a population of Th1-type cells to produce cytokines such as IFN-gamma, resulting in suppression of Th2-type responses, i.e. IL4 secretion. We speculate that the changes in the balance of relevant antigen-induced cytokine synthesis seen...Continue Reading

Citations

Feb 11, 2010·International Archives of Allergy and Immunology·Babu GonipetaVenu Gangur
Mar 19, 2014·The Journal of Allergy and Clinical Immunology·Scott H SichererHugh A Sampson
Nov 22, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T H Scott-TaylorS Strobel
Feb 19, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Robert J BoyleMimi L K Tang
Mar 5, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J M SmartA S Kemp
Feb 22, 2011·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Susan Prescott, Katrina J Allen
Jul 20, 2010·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Sara TomicićMalin Fagerås Böttcher
May 4, 2015·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Laura PerezábadIván López-Expósito
Apr 19, 2011·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Aito Ueno-YamanouchiJan Storek
May 8, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J M Smart, A S Kemp

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