PMID: 8947592Nov 1, 1996Paper

Cytokine production in hearts of Trypanosoma cruzi-infected CBA mice: Do cytokine patterns in chronic stage reflect the establishment of myocardial pathology?

Scandinavian Journal of Immunology
D SunnemarkR A Harris

Abstract

The authors analysed cytokine production in hearts of Trypanosoma cruzi-infected CBA-J mice by in situ immunocytochemical staining. Cellular infiltrates were recorded in hearts from both acute and chronic stages, but were not apparent in control hearts. In the acute heart, CD8 cells predominated, with associated production of IL-4, IL-6 and TNF-alpha. Cytokine production was characterized by IL-4, IL-5, IL-6 and TNF-alpha in the chronic heart, and numbers of CD4 and CD8 cells were more equal. At this stage, calcified infarctions and associated fibrosis were apparent, mimicking chronic human Chagas' heart pathology. The authors consider the CBA mouse an appropriate model of chronic T. cruzi infection, and suggest that local cytokine production reflects establishment of heart pathology.

Citations

Aug 10, 2001·Diseases of the Colon and Rectum·C E CorbettJ Gama-Rodrigues
Jul 25, 2012·Lipids in Health and Disease·Ayman Samir Farid, Yoichiro Horii
Jan 27, 2004·The American Journal of Pathology·Milena B P SoaresRicardo Ribeiro-dos-Santos
Nov 11, 1999·Current Opinion in Neurology·P M Moore
Jul 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·R L TarletonL Zhang
Aug 7, 2019·Experimental and Therapeutic Medicine·Iulia-Ioana MorarRemus-Ioan Orăsan

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