PMID: 8957209Nov 1, 1996Paper

Cytokine profile in chronic cardiac failure

European Journal of Clinical Investigation
I C SteeleD P Nicholls

Abstract

Elevated tumour necrosis factor alpha (TNF-alpha) has been demonstrated in chronic cardiac failure (CCF) and may relate to severity of CCF and development of cachexia. We measured TNF receptor p55 in addition to TNF-alpha in an attempt to improve the detection rate of TNF-alpha activation, and simultaneously measured interleukin 6 (IL-6), interleukin 8 (IL-8) and C-reactive protein. Thirty-four patients with CCF and 24 control subjects were studied. Only TNF receptor p55 [6.95 (0.77-42.3) vs. 5.52 (1.50-13.36) ng mL-1 (median (range)] and IL-6 [0.335 (0-9.79) vs. 0(0-14.71) pg mL-1) were significantly elevated in patients compared with control subjects (both P < 0.05). All inflammatory markers were more frequently elevated in patients, but none correlated with any of the clinical parameters studied. Reasons for inflammatory marker elevation in CCF are uncertain, but future studies should measure the p55 TNF receptor and IL-6 in addition to TNF-alpha, to improve detection of cytokine activity.

Citations

Oct 9, 2008·Journal of Cardiovascular Pharmacology·Michel J SabbaghFrancis G Spinale
Jun 27, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Chitose IshikawaMinoru Horie
Mar 29, 2003·Expert Opinion on Biological Therapy·Klaus P Machold, Josef S Smolen
Dec 22, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Christian F BulcaoShahab A Akhter
Mar 31, 2009·Journal of Cardiac Failure·José Paulo AraújoPaulo Bettencourt
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Feb 28, 2006·Journal of Cardiac Failure·Sanjiv J ShahAndrew D Michaels
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