Cytokine profile in plasma of severe COVID-19 does not differ from ARDS and sepsis

JCI Insight
Jennifer WilsonAngela J Rogers

Abstract

BACKGROUNDElevated levels of inflammatory cytokines have been associated with poor outcomes among COVID-19 patients. It is unknown, however, how these levels compare with those observed in critically ill patients with acute respiratory distress syndrome (ARDS) or sepsis due to other causes.METHODSWe used a Luminex assay to determine expression of 76 cytokines from plasma of hospitalized COVID-19 patients and banked plasma samples from ARDS and sepsis patients. Our analysis focused on detecting statistical differences in levels of 6 cytokines associated with cytokine storm (IL-1β, IL-1RA, IL-6, IL-8, IL-18, and TNF-α) between patients with moderate COVID-19, severe COVID-19, and ARDS or sepsis.RESULTSFifteen hospitalized COVID-19 patients, 9 of whom were critically ill, were compared with critically ill patients with ARDS (n = 12) or sepsis (n = 16). There were no statistically significant differences in baseline levels of IL-1β, IL-1RA, IL-6, IL-8, IL-18, and TNF-α between patients with COVID-19 and critically ill controls with ARDS or sepsis.CONCLUSIONLevels of inflammatory cytokines were not higher in severe COVID-19 patients than in moderate COVID-19 or critically ill patients with ARDS or sepsis in this small cohort. Broad ...Continue Reading

References

May 4, 2017·Seminars in Immunopathology·Rudragouda Channappanavar, Stanley Perlman
Aug 7, 2018·The Lancet. Respiratory Medicine·Carolyn S CalfeeUNKNOWN Irish Critical Care Trials Group
Mar 7, 2020·Nature Communications·Michael B MayhewTimothy E Sweeney
Mar 29, 2020·The Journal of Clinical Investigation·Guang ChenQin Ning
Mar 30, 2020·Lancet·Andrew I Ritchie, Aran Singanayagam
May 8, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Holden T MaeckerLorinda S Chung
May 25, 2020·Cytokine & Growth Factor Reviews·Francesca CoperchiniMario Rotondi

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Citations

Aug 28, 2020·Expert Review of Anti-infective Therapy·Daniel Echeverría-EsnalSantiago Grau
Sep 19, 2020·JAMA Internal Medicine·Lieuwe D J BosCarolyn S Calfee
Aug 19, 2020·Nature Medicine·Adam G LaingAdrian C Hayday
Oct 7, 2020·Annals of the New York Academy of Sciences·Brittany WoodbyGiuseppe Valacchi
Oct 7, 2020·The Journal of Clinical Investigation·Franco R D'Alessio, Nicola M Heller
Oct 29, 2020·Journal of Intensive Care Medicine·Raghu R ChivukulaC Corey Hardin
Dec 29, 2020·Journal of Diabetes and Its Complications·Wanqi YuPeng Jia
Feb 10, 2021·Critical Care : the Official Journal of the Critical Care Forum·Yue ZhangAng Li
Feb 2, 2021·Heart & Lung : the Journal of Critical Care·Joshua K SalabeiUma G Iyer
Nov 17, 2020·Frontiers in Immunology·Howard M JohnsonChulbul M Ahmed
Nov 25, 2020·JCI Insight·Michael S AbersLuigi D Notarangelo
Jan 11, 2021·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Dennis G MoledinaF Perry Wilson
Jan 2, 2021·Seminars in Arthritis and Rheumatism·Shunli TangHong Fang
Feb 11, 2021·Cell Reports Medicine·Marios KoutsakosKatherine Kedzierska
Jan 13, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Joseph BalnisAriel Jaitovich
Jan 31, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Isaac J JensenVladimir P Badovinac
Feb 23, 2021·Frontiers in Immunology·Charles Ochieng' OlwalSamuel Duodu
Mar 12, 2021·BMJ : British Medical Journal·Amy H AttawayUmur Hatipoğlu
Mar 23, 2021·Clinical & Translational Immunology·Ingrid Carvacho, Matthias Piesche
Nov 9, 2020·Immunology Letters·Lorenzo SalvatiLorenzo Cosmi
Apr 15, 2021·Nature Reviews. Immunology·Simon A Jones, Christopher A Hunter
Apr 20, 2021·The Lancet. Respiratory Medicine·Oliver J McElvaneyNoel G McElvaney
May 9, 2021·Journal for Immunotherapy of Cancer·Holden T Maecker
Oct 12, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Carole NagantFrancis Corazza
Jun 5, 2021·Clinical Case Reports·Mabrouk Al-RasheediKhawaja Husnain Haider
Jun 16, 2021·The Journal of Experimental Medicine·Aaron J WilkCatherine A Blish
Jul 22, 2021·Molecular Aspects of Medicine·Surender RawatArup Banerjee
Aug 8, 2021·International Journal of Molecular Sciences·Athanassios FragoulisLucy Kathleen Reiss
Jul 10, 2021·Experimental Physiology·John A Clark, Nazima Pathan
Aug 10, 2021·Frontiers in Physiology·Sabina SahanicIvan Tancevski
Aug 28, 2021·Nature Communications·Aartik SarmaCharles R Langelier
Aug 28, 2021·International Journal of Molecular Sciences·Yadira PalaciosLeslie Chavez-Galan
Aug 31, 2021·PloS One·Ana Sofía Herrera-Van OostdamYamilé López-Hernández
Aug 31, 2021·Journal of Medical Virology·Karolina AkinosoglouCharalambos Gogos
May 29, 2021·Critical Care Medicine·Samuel J Minkove, Parizad Torabi-Parizi

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Methods Mentioned

BETA
ELISA
blood draws
Assay
PCA

Software Mentioned

R
ggfortify R

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