PMID: 9423855Jan 10, 1998Paper

Cytokine profiles for peripheral blood lymphocytes from patients with active pulmonary tuberculosis and healthy household contacts in response to the 30-kilodalton antigen of Mycobacterium tuberculosis

Infection and Immunity
M TorresE Sada

Abstract

Patients with active tuberculosis (TB) have a stronger humoral but a poorer cellular immune response to the secreted 30-kDa antigen (Ag) of Mycobacterium tuberculosis than do healthy household contacts (HHC), who presumably are more protected against disease. The basis for this observation was studied by examining the Th1 (interleukin 2 [IL-2] and gamma interferon [IFN-gamma])- and Th2 (IL-10 and IL-4)-type cytokines produced in response to the 30-kDa Ag by peripheral blood mononuclear cells (PBMC) from patients with active pulmonary TB (n = 7) and from HHC who were tuberculin (purified protein derivative) skin test positive (n = 12). Thirty-kilodalton-Ag-stimulated PBMC from TB patients produced significantly lower levels of IFN-gamma (none detectable) than did those from HHC (212 +/- 73 pg/ml, mean +/- standard error) (P < 0.001). Likewise, 30-kDa-Ag-stimulated PBMC from TB patients failed to express IFN-gamma mRNA by reverse transcription-PCR, whereas cells from HHC expressed the IFN-gamma gene. In contrast, 30-kDa-Ag-stimulated PBMC from TB patients produced significantly higher levels of IL-10 (403 +/- 80 pg/ml) than did those from HHC (187 +/- 66 pg/ml) (P < 0.013), although cells from both groups expressed the IL-10 gene...Continue Reading

References

Jun 1, 1992·Immunology Today·M Howard, A O'Garra
Dec 1, 1992·Microbiological Reviews·H G Wiker, M Harboe
Jan 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M HarboeS Nagai
Oct 1, 1991·Immunology Today·P Scott, S H Kaufmann
Feb 1, 1991·Infection and Immunity·D V HavlirJ J Ellner
Dec 1, 1989·The Journal of Experimental Medicine·D F FiorentinoT R Mosmann
Mar 1, 1989·Reviews of Infectious Diseases·P E Fine
Dec 1, 1993·The Journal of Experimental Medicine·J L FlynnB R Bloom
Aug 1, 1995·Infection and Immunity·M ZhangP F Barnes
Feb 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·M A HorwitzG Harth
Apr 1, 1994·American Journal of Respiratory and Critical Care Medicine·D S RobinsonR J Shaw
Dec 1, 1993·The Journal of Experimental Medicine·A M CooperI M Orme
Aug 1, 1993·Infection and Immunity·P F BarnesR L Modlin
Jun 1, 1993·The Journal of Infectious Diseases·I M OrmeW H Boom
Aug 1, 1996·Nature Medicine·K HuygenJ B Ulmer

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Citations

Sep 16, 1998·Clinical and Experimental Immunology·A D Howard, B S Zwilling
Dec 23, 2008·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Eliana PeresiJussara Marcondes-Machado
Jun 19, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alexandre S AlmeidaJohn L Ho
Aug 26, 2009·Scandinavian Journal of Immunology·E AktasG Deniz
Apr 8, 1999·Clinical and Experimental Immunology·A D Howard, B S Zwilling
May 3, 2000·The Journal of Clinical Investigation·V A BoussiotisA E Goldfeld
Sep 15, 2004·Transactions of the Royal Society of Tropical Medicine and Hygiene·Alison M ElliottJames A G Whitworth
Mar 23, 2013·Annual Review of Immunology·Anne O'GarraMatthew P R Berry
Jul 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·S K SchwanderE Sada
Mar 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Buka SamtenPeter F Barnes
Feb 4, 2003·Clinical and Experimental Immunology·J TalrejaN K Ganguly
Dec 7, 2007·Scandinavian Journal of Immunology·J-S LeeE-K Jo
Dec 20, 2012·Pulmonary Medicine·Yone Vila Nova CavalcantiValéria Rêgo Alves Pereira
Apr 5, 2002·Clinical Microbiology Reviews·Reinout van CrevelJos W M van der Meer
Jul 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·G T Seah, G A Rook
Jun 26, 2007·Respirology : Official Journal of the Asian Pacific Society of Respirology·Jae-Hee OhChang-Hwa Song
Oct 8, 2005·American Journal of Respiratory and Critical Care Medicine·Claudia CarranzaStephan K Schwander
Apr 20, 2004·FEMS Immunology and Medical Microbiology·Sulochana D DasC Prabha
Jan 14, 2009·Journal of Clinical Laboratory Analysis·Y V N CavalcantiN Lucena-Silva

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