Cytokine profiles in acute liver failure treated with albumin dialysis

Artificial Organs
I IlonenH Isoniemi

Abstract

Cytokines are released within the liver in response to hepatic injury, and acute liver failure (ALF) triggers systemic inflammation. Pro-inflammatory (tumor necrosis factor-alpha [TNF-alpha] and interleukin-8 [IL-8]) and anti-inflammatory (interleukin-10 [IL-10] and interleukin-6 [IL-6]) cytokines and the lymphocyte activation marker (interleukin-2-soluble receptor alpha chain [IL-2sRalpha]) were monitored in 49 ALF patients considered for liver transplantation and treated with albumin dialysis (molecular adsorbent recirculating system [MARS]). Twenty-six patients were categorized by clinical outcome as "good" (native liver recovered) and 23 as "poor" (patient bridged to liver transplantation or deceased). MARS did not clearly affect cytokine profiles during treatment; only IL-10 levels decreased in the whole patient population and mostly in patients with the worst prognosis. In the good outcome group, IL-8 and IL-6 levels decreased during treatment; on the contrary, in poor outcome patients IL-6 levels even increased. Initial IL-2sRalpha levels were higher in poor outcome patients relative to the good outcome subset. Cytokine profiles seem to differ in ALF according to patient outcome. A deeper understanding of cytokine patter...Continue Reading

References

Oct 1, 1989·Critical Care Medicine·P DamasP Franchimont
Dec 1, 1987·British Journal of Cancer·P SelbyJ Humphreys
Sep 30, 1999·European Journal of Gastroenterology & Hepatology·K J Simpson
Mar 23, 2000·Journal of Hepatology·N Fausto
Apr 18, 2000·Chest·S M Opal, V A DePalo
Sep 9, 2000·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·J StangeU T Hopt
Feb 17, 2001·American Journal of Respiratory and Critical Care Medicine·R S Munford, J Pugin
May 9, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P J FerretF Batteux
May 18, 2001·Molecular Therapy : the Journal of the American Society of Gene Therapy·N HechtJ H Axelrod
Nov 14, 2001·Current Opinion in Nephrology and Hypertension·S R MitznerR Schmidt
Sep 26, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ludger LeifeldUlrich Spengler
Oct 31, 2002·American Journal of Respiratory and Critical Care Medicine·Thierry Fumeaux, Jérôme Pugin
Nov 9, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Bjørn BrandsaeterKristian Bjøro
Jan 30, 2003·Annals of Medicine·Annika TakalaHeikki Repo
May 15, 2003·Mediators of Inflammation·Mehmet TarakçioğluRamazan Kocabaş
Sep 7, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Sambit SenRajiv Jalan
Dec 8, 2004·Transplant International : Official Journal of the European Society for Organ Transplantation·Arttu LahdenperäHelena Isoniemi
Jan 25, 2005·Journal of Hepatology·Hermann E WasmuthFrank Lammert
Apr 5, 2005·Toxicologic Pathology·George A Parker, Catherine A Picut
Feb 1, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Nelson FaustoKimberly J Riehle
Mar 25, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Pen-Chung TanShou-Dong Lee

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Citations

Nov 1, 2012·Journal of Pediatric Gastroenterology and Nutrition·John BucuvalasRobert H Squires
Feb 28, 2009·Artificial Organs·Paul S Malchesky
Sep 29, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Andreas KortgenMichael Bauer

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