PMID: 9437396Jan 23, 1998Paper

Cytokine profiles of cells extracted from humans with periodontal diseases

Journal of Dental Research
E Gemmell, G J Seymour

Abstract

FACS analysis was used to determine the percent interferon (IFN)-gamma-, interleukin (IL)-4-, IL-10-, and CD30-positive T-cells extracted from adult periodontitis (AP) and healthy/gingivitis (H/G) subjects. Additionally, the percentages of IL-1 beta-, IL-10- and IL-12-producing B-cells and macrophages were ascertained. The percent IL-10+ CD8 cells extracted from AP lesions was decreased compared with H/G tissues (p = 0.033), and the percent CD30+ CD4 (p = 0.001) and CD30+ CD8 (p = 0.028) cells was higher in AP than in H/G tissues. The percentages of IL-1 beta + macrophages (p = 0.003) and IL-12+ B-cells (p = 0.034) were both higher in AP lesions than in H/G tissues. The specific effect of Porphyromonas gingivalis on the cytokine profiles of peripheral blood mononuclear cells isolated from P. gingivalis-infected AP and H/G patients was also determined. While there were no significant differences in the percent cytokine-positive T-cells after stimulation with P. gingivalis outer membrane antigens (OM) for 6 days compared with cells incubated in medium only, the percent CD30+ CD4 cells increased significantly (p = 0.047 and p = 0.063 for AP and H/G groups, respectively). There was also an increase in the percent IL-1 beta + B-cell...Continue Reading

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Citations

Oct 18, 2011·Odontology·Zuhal Yetkin AyNilgün Kapucuoğlu
Feb 11, 2000·Archives of Oral Biology·T NakajimaG J Seymour
Jan 12, 2001·Oral Microbiology and Immunology·E GemmellG J Seymour
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Dec 11, 2002·Journal of Clinical Periodontology·Reiner MengelLavin Flores-De-Jacoby
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Feb 24, 2001·Clinical and Experimental Immunology·D F LappinD F Kinane
Jul 27, 2001·Clinical and Experimental Immunology·E GemmellG J Seymour
Jul 25, 2006·Journal of Dental Research·C W Cutler, R Jotwani
Jul 15, 2005·Annals of Periodontology·Denis F Kinane, David F Lappin
Nov 6, 2002·Journal of Periodontology·Wihaskoro SosrosenoGregory J Seymour
Apr 6, 2006·Journal of Periodontology·Erica GemmellGregory J Seymour
Aug 15, 2001·Acta Odontologica Scandinavica·G J Seymour, E Gemmell
Aug 15, 2001·Acta Odontologica Scandinavica·D F Kinane, D F Lappin
Sep 1, 2005·Journal of Clinical Periodontology·Tord Berglundh, Mauro Donati
Apr 7, 2005·Journal of Clinical Periodontology·Keiso TakahashiShin Kitetsu
Apr 28, 2005·Periodontology 2000·Jørgen Slots
Mar 13, 2003·Journal of Clinical Periodontology·Tord BerglundhLeonid Padyukov
Apr 17, 2004·Journal of Clinical Periodontology·J R GonzalesJ Meyle
Apr 27, 2004·Periodontology 2000·Erica Gemmell, Gregory J Seymour
Jan 12, 2007·Periodontology 2000·Erica GemmellGregory J Seymour
Apr 25, 2007·Journal of Clinical Periodontology·J R GonzalesJ Meyle
Feb 26, 2011·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Jean SuvanNikos Donos
Mar 27, 2003·Periodontology 2000·Catherine M E ChampagneSteven Offenbacher

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