Abstract
Information on cytokine profiles in fungal sepsis (FS), an important cause of mortality in extremely low birthweight (ELBW) infants, is lacking. We hypothesized that cytokine profiles in the first 21 d of life in ELBW infants with FS differ from those with bacterial sepsis (BS) or no sepsis (NS). In a secondary analysis of the National Institute of Child Health and Human Development Cytokine study, three groups were defined-FS (≥1 episode of FS), BS (≥1 episode of BS without FS), and NS. Association between 11 cytokines assayed in dried blood spots obtained on days 0-1, 3 ± 1, 7 ± 2, 14 ± 3, and 21 ± 3 and sepsis group was explored. Of 1,066 infants, 89 had FS and 368 had BS. As compared with BS, FS was more likely to be associated with lower birthweight, vaginal delivery, patent ductus arteriosus, postnatal steroids, multiple central lines, longer respiratory support and hospital stay, and higher mortality (P < 0.05). Analyses controlling for covariates showed significant group differences over time for interferon-γ (IFN-γ), interleukin (IL)-10, IL-18, transforming growth factor-β (TGF-β), and tumor necrosis factor-α (TNF-α) (P < 0.05). Significant differences in profiles for IFN-γ, IL-10, IL-18, TGF-β, and TNF-α in FS, BS, or...Continue Reading
References
Oct 1, 1996·The Journal of Pediatrics·J MesserU Simeoni
Apr 1, 1997·The Pediatric Infectious Disease Journal·A PaneroC Chiesa
Oct 27, 1998·Lancet·H KüsterG Simbruner
Jan 29, 1999·Lancet·P E McKinney, M Hauswald
Jan 29, 1999·Lancet·E E OnalB Adam
Aug 11, 2000·BMJ : British Medical Journal·A Berger
Jun 26, 2001·European Journal of Pediatrics·C RomagnoliG Tortorolo
Dec 26, 2001·Journal of Clinical Epidemiology·H DøllnerR Austgulen
Aug 8, 2002·Pediatrics·Barbara J StollW Kenneth Poole
Mar 29, 2003·Journal of Perinatal Medicine·Blanca E GonzalezVineet Bhandari
Apr 30, 2003·Archives of Disease in Childhood. Fetal and Neonatal Edition·P C NgT F Fok
Jan 3, 2004·American Journal of Perinatology·Gary LaboradaMirjana Nesin
Jul 10, 2004·The Journal of Infectious Diseases·Weitao HuangPaul Schwarzenberger
Jul 20, 2004·Clinical Microbiology Reviews·David Kaufman, Karen D Fairchild
Jul 24, 2004·Clinical and Experimental Immunology·G HodgeH Zola
Nov 18, 2004·JAMA : the Journal of the American Medical Association·Barbara J StollUNKNOWN National Institute of Child Health and Human Development Neonatal Research Network
Aug 6, 2005·Clinical Chemistry·Kristin SkogstrandDavid M Hougaard
Apr 15, 2006·Clinical Chemistry·Pak C NgTai F Fok
Apr 21, 2006·The New England Journal of Medicine·Stephen W Lagakos
Jun 13, 2006·Current Opinion in Immunology·Tobias M HohlEric G Pamer
Dec 2, 2006·Current Opinion in Immunology·Sharon M Wahl
Jan 11, 2007·Pediatric Research·Pak C NgTai F Fok
May 9, 2007·Nature Immunology·Eva V Acosta-RodriguezGiorgio Napolitani
Nov 6, 2007·Frontiers in Bioscience : a Journal and Virtual Library·Jeffrey J Yu, Sarah L Gaffen
Dec 18, 2007·Seminars in Immunology·Nico Ghilardi, Wenjun Ouyang
Dec 21, 2007·Microbiology and Immunology·Goro Matsuzaki, Masayuki Umemura
Jan 8, 2008·Cytokine·Fang Shen, Sarah L Gaffen
Feb 16, 2008·Mediators of Inflammation·A Nese Citak KurtErdal Yilmaz
Feb 19, 2008·Pharmacology & Therapeutics·Bhanu P PappuChen Dong
May 23, 2008·Journal of Immunological Methods·Kristin SkogstrandDavid M Hougaard
Jul 16, 2008·Molecular & Cellular Proteomics : MCP·Stephen F KingsmoreJ David M Edgar
Dec 2, 2008·Mediators of Inflammation·Birsen UcarErtugrul Colak
Dec 9, 2008·Jornal de pediatria·Jamil P S CaldasRômulo T D Oliveira
Feb 11, 2009·The Journal of Experimental Medicine·Heather R ContiSarah L Gaffen
Mar 25, 2009·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Ana Carolina CancelierFelipe Dal-Pizzol
Oct 23, 2009·Journal of Perinatology : Official Journal of the California Perinatal Association·B Shouman, R Badr
Nov 6, 2009·Mycoses·Suna Serife OguzUgur Dilmen
Dec 25, 2009·Pediatric Research·Beena G SoodUNKNOWN NICHD neonatal research network
Jan 21, 2010·Scandinavian Journal of Infectious Diseases·Alaa A H ZeitounEdward F Bell
Sep 30, 2010·Pediatrics·Daniel K BenjaminUNKNOWN Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
Dec 15, 2010·Cytokine·Robert L SchelonkaUNKNOWN NICHD Neonatal Research Network
Dec 21, 2010·The Journal of Pediatrics·David A KaufmanPeter Patrick
Jan 6, 2011·Scandinavian Journal of Immunology·E HotouraS Andronikou
Jul 30, 2011·The Journal of Pediatrics·Waldemar A CarloUNKNOWN Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
Citations
Jun 12, 2014·Equine Veterinary Journal·E S HackettP M McCue
Aug 6, 2013·Cytokine·Jolice P van den BergRuurd M van Elburg
Jul 30, 2014·NeuroImage. Clinical·Jessica RoseNaama Barnea-Goraly
Aug 26, 2014·Biological Psychiatry·Philip Rising NielsenPreben Bo Mortensen
Dec 16, 2017·American Journal of Reproductive Immunology : AJRI·Shelley M LawrenceJames L Wynn
Jan 17, 2014·Pediatric Research·Olaf Dammann, Alan Leviton
Sep 11, 2014·Journal of Perinatal Medicine·Steven J KorzeniewskiSonia S Hassan
Oct 16, 2016·Journal of Neuroinflammation·Yenis M Gutierrez-MurgasJessica N Snowden
Apr 13, 2019·Nature Communications·Stephan DreschersKlaus Tenbrock
Dec 14, 2018·Current Opinion in Pediatrics·Zachary Willis, Annabelle de St Maurice
Apr 4, 2017·Journal of Immunology Research·Kh S KhaertynovA A Rizvanov
Feb 23, 2017·Frontiers in Pediatrics·Steven L RaymondLyle L Moldawer
Feb 26, 2021·The Science of the Total Environment·Stephanie N KennedyTodd M O'Hara
Jul 31, 2021·BioMed Research International·Homayoun AsadzadehMohammad R K Mofrad