Cytokine profiles of preterm neonates with fungal and bacterial sepsis.

Pediatric Research
Beena G SoodEunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network

Abstract

Information on cytokine profiles in fungal sepsis (FS), an important cause of mortality in extremely low birthweight (ELBW) infants, is lacking. We hypothesized that cytokine profiles in the first 21 d of life in ELBW infants with FS differ from those with bacterial sepsis (BS) or no sepsis (NS). In a secondary analysis of the National Institute of Child Health and Human Development Cytokine study, three groups were defined-FS (≥1 episode of FS), BS (≥1 episode of BS without FS), and NS. Association between 11 cytokines assayed in dried blood spots obtained on days 0-1, 3 ± 1, 7 ± 2, 14 ± 3, and 21 ± 3 and sepsis group was explored. Of 1,066 infants, 89 had FS and 368 had BS. As compared with BS, FS was more likely to be associated with lower birthweight, vaginal delivery, patent ductus arteriosus, postnatal steroids, multiple central lines, longer respiratory support and hospital stay, and higher mortality (P < 0.05). Analyses controlling for covariates showed significant group differences over time for interferon-γ (IFN-γ), interleukin (IL)-10, IL-18, transforming growth factor-β (TGF-β), and tumor necrosis factor-α (TNF-α) (P < 0.05). Significant differences in profiles for IFN-γ, IL-10, IL-18, TGF-β, and TNF-α in FS, BS, or...Continue Reading

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Citations

Jun 12, 2014·Equine Veterinary Journal·E S HackettP M McCue
Aug 26, 2014·Biological Psychiatry·Philip Rising NielsenPreben Bo Mortensen
Dec 16, 2017·American Journal of Reproductive Immunology : AJRI·Shelley M LawrenceJames L Wynn
Jan 17, 2014·Pediatric Research·Olaf Dammann, Alan Leviton
Dec 14, 2018·Current Opinion in Pediatrics·Zachary Willis, Annabelle de St Maurice
Apr 4, 2017·Journal of Immunology Research·Kh S KhaertynovA A Rizvanov
Feb 23, 2017·Frontiers in Pediatrics·Steven L RaymondLyle L Moldawer
Jul 31, 2021·BioMed Research International·Homayoun AsadzadehMohammad R K Mofrad

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