Cytokine profiles show heterogeneity of interferon-β response in multiple sclerosis patients

Neurology. Neuroimmunology and Neuroinflammation
Harald HegenR C Axtell

Abstract

To evaluate serum cytokine profiles for their utility to determine the heterogeneous responses to interferon (IFN)-β treatment in patients with multiple sclerosis (MS). Patients with relapsing-remitting MS (RRMS) or clinically isolated syndrome receiving de novo IFN-β treatment were included in this prospective, observational study. Number of relapses and changes in disability were assessed 2 years prior to and 2 years after initiation of treatment. Sera were collected at baseline and after 3 months on therapy. Cytokine levels in sera were assessed by Luminex multiplex assays. Baseline cytokine profiles were grouped by hierarchical clustering analysis. Demographic features, changes in cytokines, and clinical outcome were then assessed in the clustered patient groups. A total of 157 patients were included in the study and clustered into 6 distinct subsets by baseline cytokine profiles. These subsets differed significantly in their clinical and biological response to IFN-β therapy. Two subsets were associated with patients who responded poorly to therapy. Two other subsets, associated with a good response to therapy, showed a significant reduction in relapse rates and no worsening of disability. Each subset also had differential ...Continue Reading

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Citations

Apr 7, 2018·Expert Opinion on Biological Therapy·Laura DumitrescuRadu Tanasescu
Nov 9, 2018·Expert Opinion on Pharmacotherapy·Ludwig Rasche, Friedemann Paul
Sep 14, 2019·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Miaomiao HouXinyi Li
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