Cytokine profiling and post-transfusion haemoglobin increment in patients with haematological diseases

Vox Sanguinis
Ø WendelboH Reikvam

Abstract

In a previous pilot study, we demonstrated significantly lower haemoglobin (Hb) increment after red-blood-cell (RBC) transfusions in febrile patients compared to patients without fever. The aim of this study was to examine associations between inflammatory mediators and post-transfusion haemoglobin increment in patients with haematological diseases. Twenty-seven patients (eight women, 19 men), median age 56 years receiving RBC transfusion, were included in the study. Hb increment per unit transfused was corrected for estimated patient blood volume and the amount of Hb transfused. A wide spectrum of inflammatory mediators was determined by multiplex technology. Association between post-transfusion haemoglobin increment, plasma inflammatory mediators and patient characteristics was analysed using a mixed linear regression model. Febrile patients had significantly lower corrected Hb increment, significantly increased values of IL-6, IL-8, IL-10 and G-CSF, significantly reduced levels of CCL5 and CXCL10, and significantly higher pretransfusion levels of CRP. There was a significant association between pretransfusion CRP levels and corrected Hb increment for the whole patient cohort, but not within each of the two groups. Results de...Continue Reading

References

Jan 1, 1990·The Journal of Infectious Diseases·J G CannonB Chernow
Sep 11, 1980·The New England Journal of Medicine·C F NathanZ A Cohn
Jul 1, 1995·The Journal of Infectious Diseases·B GårdlundB Wretlind
Jun 30, 1994·The New England Journal of Medicine·C B Saper, C D Breder
Apr 1, 1993·The Journal of Clinical Investigation·D M VigushinP N Hawkins
Apr 1, 1996·International Archives of Allergy and Immunology·G Luheshi, N Rothwell
Aug 1, 1997·The Pediatric Infectious Disease Journal·D L Jaye, K B Waites
Feb 11, 1999·The New England Journal of Medicine·C Gabay, I Kushner
Mar 19, 1999·The Journal of Infectious Diseases·C A Dinarello
Jun 8, 2001·Seminars in Oncology·H Ludwig, K Strasser
Oct 13, 2001·Cancer·J Glaspy
Sep 30, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Heinz LudwigDirk Schrijvers
Apr 23, 2008·Current Protocols in Bioinformatics·Anne Kristin StavrumBjarte Dysvik
Dec 15, 2010·Transfusion Medicine·H ReikvamUNKNOWN BEST collaborative
Oct 25, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Håkon ReikvamØystein Bruserud

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