Cytokine receptor dimerization and activation: prospects for small molecule agonists

Bioorganic & Medicinal Chemistry
Dale L Boger, Joel Goldberg

Abstract

Ligand-induced dimerization of cell surface receptors has emerged as a general mechanism for the initiation of signal transduction. A number of therapeutically important receptor families are believed to be activated by this process. Recently available structural information, particularly for the erythropoietin receptor, has provided insight into the mechanism of receptor activation. These findings have also revealed important constraints on the nature of receptor-agonist complexes. The prospects of discovering small-molecule mimetics of such receptor agonists are discussed, including strategies which have led to the identification of a small number of peptide and non-peptide cytokine mimetics.

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Citations

Sep 10, 2002·Methods : a Companion to Methods in Enzymology·Mario MelladoJosé Miguel Rodríguez-Frade
May 26, 2011·Journal of the American Chemical Society·Landon R WhitbyDale L Boger
Apr 2, 2009·Journal of the American Chemical Society·Alex ShaginianDale L Boger
Jun 9, 2005·Current Opinion in Chemical Biology·Aaron B BeelerJohn A Porco
Apr 23, 2004·Leukemia & Lymphoma·Deepa B Shankar, Kathleen M Sakamoto
Sep 23, 2006·Expert Opinion on Biological Therapy·Stephen J Szilvassy
Oct 6, 2009·Bioorganic & Medicinal Chemistry Letters·Jin ShiDale L Boger
Jun 1, 2018·Journal of Cell Science·Katherine H FisherMartin P Zeidler
Mar 25, 2006·Angewandte Chemie·Laura L KiesslingLaura E Strong
Oct 11, 2012·Critical Reviews in Biochemistry and Molecular Biology·Mariya Atanasova, Adrian Whitty
Feb 11, 2020·Chemical Society Reviews·Jingying LiHuanghao Yang
Mar 1, 2006·Expert Review of Endocrinology & Metabolism·Rebecca A Pelekanos, Michael J Waters
Jan 24, 2002·Journal of the American Chemical Society·Joel GoldbergDale L Boger
Apr 1, 2010·Chemical Reviews·Adrian FeganCarston R Wagner

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