Cytokine regulation of antigen-driven immunoglobulin production in filarial parasite infections in humans

The Journal of Clinical Investigation
C L KingT B Nutman

Abstract

To define the immunoregulatory mechanisms underlying serum IgE levels found in patients with filariasis, we studied polyclonal IgE production by peripheral blood mononuclear cells (PBMC) from 15 patients with filarial infections, with a focus on the role of interleukin-4 (IL-4) and interferon-gamma (IFN-gamma) in the generation and regulation of the response. Spontaneous in vitro IgE production was elevated in 10 of the 15 patients (836-6,464 pg/ml; normals, less than 500 pg/ml). Addition of filarial parasite antigen to PBMC cultures significantly stimulated polyclonal IgE production in an antigen dose-dependent manner in 10 of 12 patients tested (P less than 0.001). The essential role of IL-4 in the generation of this response was demonstrated when simultaneous addition of anti-IL-4 completely inhibited antigen-stimulated IgE production in all 10 patients studied. An inhibitory role of endogenously produced IFN-gamma was also indicated when the addition of anti-IFN-gamma to the cultures significantly augmented filarial antigen-stimulated IgE production by 33-1,238% in these same patients. Addition of 10-1,000 U/ml of recombinant human IFN-gamma to PBMC completely inhibited parasite antigen-induced IgE production. This study de...Continue Reading

References

Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·C L KingT B Nutman
Feb 1, 1988·The Journal of Experimental Medicine·A MuraguchiT Kishimoto

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Citations

May 1, 1992·Parasitology Today·N R LynchM Perez
Aug 1, 1991·Current Opinion in Immunology·G E Grau, R L Modlin
Mar 1, 1991·Immunology Today·C L King, T B Nutman
Feb 1, 1992·Immunobiology·M E SelkirkM Yazdanbakhsh
Dec 1, 1991·Current Opinion in Immunology·J E de VriesH Yssel
Mar 1, 1993·The Journal of Clinical Investigation·M YamamuraR L Moy
Apr 1, 1993·The Journal of Clinical Investigation·C PirmezR L Modlin
Nov 2, 2013·Allergy, Asthma & Immunology Research·Pernille Munk FrandsenPeter Oluf Schiøtz
Apr 2, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Simon MetenouThomas B Nutman
Nov 1, 1995·Clinical and Experimental Immunology·R RiganòA Siracusano
Aug 26, 1998·Infection and Immunity·S Jain-VoraJ A Whitsett

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