Cytokine regulation of HLA on thyroid epithelial cells

Clinical and Experimental Immunology
K MigitaM Matsunaga

Abstract

The regulation of class I and class II HLA expression in human thyroid follicular cells was studied in vitro. Tumour necrosis factor-alpha (TNF-alpha) enhanced the expression of class I antigen on thyrocytes, but these cytokines had little effect on the expression of class II antigen. Interleukin-1 beta (IL-1 beta) and interleukin-6 (IL-6) did not affect class I and class II antigen expression. The combination of interferon-gamma (IFN-gamma) with TNF-alpha or IL-1 beta enhanced the induction of class I and class II antigens, compared with the effect of IFN-gamma alone. Neither class I nor class II expression was induced by IL-6 alone or in combination with IFN-gamma. These findings suggest that TNF-alpha and IL-1 beta may have an important role in inappropriate expression of HLA antigens on thyrocytes in thyroid gland.

References

Jun 1, 1989·The Journal of Clinical Endocrinology and Metabolism·Y KawabeK Migita
Nov 1, 1985·The Journal of Clinical Endocrinology and Metabolism·A P WeetmanA S Fauci
Apr 1, 1986·The Journal of Clinical Endocrinology and Metabolism·M MatsunagaS Nagataki
Dec 1, 1987·European Journal of Immunology·M TurnerM Feldmann
Jan 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·T CollinsJ S Pober
Sep 1, 1985·The Journal of Clinical Endocrinology and Metabolism·T F Davies
Aug 1, 1985·Arthritis and Rheumatism·D D WoodD Hamerman

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Citations

Jan 1, 1993·Autoimmunity·A K RasmussenK Bendtzen
Jan 1, 1992·Autoimmunity·S Nagataki, K Eguchi

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