Cytokine regulation of natural killer cell effector functions

BioFactors
Norberto Walter Zwirner, Carolina Inés Domaica

Abstract

Initially described as effectors of natural cytotoxicity and critical players for the control of viral infections and tumor growth, recent investigations unraveled more widespread functions for the natural killer (NK) cells. Through the establishment of a crosstalk with dendritic cells, NK cells promote T helper-1- and cytotoxic T lymphocyte-mediated immunity, whereas through the establishment of a crosstalk with macrophages, NK cells contribute to the activation of their microbicidal functions. Recent evidence has shown that NK cells also display memory, a characteristic thought to be privative of T and B cells, and that NK cells acquire their mature phenotype during a complex ontogeny program which tunes their activation threshold. Cytokines play critical roles in regulating all aspects of immune responses, including lymphoid development, homeostasis, differentiation, tolerance, and memory. Cytokines such as interleukin (IL)-2, IL-12, IL-15, IL-18, IL-21, and type I interferons constitute pivotal factors involved in the maturation, activation, and survival of NK cells. In addition, the discovery of novel cytokines is increasing the spectrum of soluble mediators that regulate NK cell immunobiology. In this review, we summarize...Continue Reading

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Citations

Oct 12, 2013·Cancer Immunology, Immunotherapy : CII·Raúl Germán SpallanzaniNorberto Walter Zwirner
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Mar 2, 2019·Journal of Leukocyte Biology·Christopher H ModyShu Shun Li
Mar 20, 2019·Scientific Reports·Nadine RadomskiMichael R Knittler
Mar 5, 2020·Cancer Immunology, Immunotherapy : CII·Raquel TarazonaRafael Solana
Aug 2, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Raúl G SpallanzaniNorberto W Zwirner
Feb 6, 2017·Frontiers in Immunology·Norberto Walter Zwirner, Andrea Ziblat
Apr 22, 2015·World Journal of Gastroenterology : WJG·Jia-Yan YaoBi-Hui Zhong
Sep 5, 2018·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Camille Guillerey
Jun 7, 2019·Viruses·Liliana Portales-CervantesJean S Marshall

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