Cytokine response in the intestinal mucosa of hamsters infected with Taenia solium

Annals of the New York Academy of Sciences
Guillermina AvilaAna Flisser

Abstract

Taenia solium grows in experimentally infected hamsters. An inflammatory reaction in the intestinal mucosa surrounding the scolex of the worms is produced. We searched for mRNA of Th1 and Th2 cytokines by in situ hybridization in intestinal biopsies. Hamsters were infected with T. solium cysticerci and necropsied on different days post infection (d.p.i.). Tissue from the small intestine was taken from the area surrounding the tapeworm scolex, fixed, and processed for histology. Antisense probes for the detection of interferon (IFN)-gamma, interleukin (IL)-4, IL-5, and IL-13 were used. Kinetics of each cytokine was defined through detection on specific mRNA by counting the number of positive infected hamsters and of positive cells per 100 enterocytes on different d.p.i. IFN-gamma was detected as of d.p.i. 2; all animals were positive on d.p.i. 4 and 8; and on d.p.i. 16, only 20% were still positive. IL-13 had a pattern similar to IFN-gamma, but all hamsters remained positive until d.p.i. 16 when the experiment was terminated. IL-4 was positive in 40% of infected hamsters on d.p.i. 6. On d.p.i. 8, IL-5 was only detected in 20% but increased to 100% by d.p.i. 16. These data suggest that tapeworms induce a mixed Th1/Th2 response wi...Continue Reading

References

Apr 1, 2004·Parasite Immunology·Jagveer RawatMark J Taylor
Aug 16, 2005·Veterinary Immunology and Immunopathology·Els N T MeeusenVernon Bowles

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Citations

Mar 2, 2010·Parasitology·A FlisserD E Jimenez-Gonzalez
Apr 14, 2012·Journal of Biomedicine & Biotechnology·Sonia Leon-Cabrera, Ana Flisser
Nov 24, 2011·International Journal of Biological Sciences·Galileo EscobedoJorge Morales-Montor
Aug 10, 2010·Experimental Parasitology·Salvador Fonseca-CoronadoAna Flisser
Mar 20, 2013·BioMed Research International·Galileo EscobedoJorge Morales-Montor
Dec 16, 2020·Research in Veterinary Science·Fela MendlovicAna Flisser

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