Cytokine responses and progression to active tuberculosis in HIV-1-infected Ugandans: a prospective study

Transactions of the Royal Society of Tropical Medicine and Hygiene
Alison M ElliottJames A G Whitworth

Abstract

Identifying correlates of immunity or susceptibility to disease promotes understanding of pathogenesis and development of diagnostic tools, treatments, and vaccines. There is evidence that type 1 cytokine responses are associated with protection against tuberculosis, and suppression of type 1, or switching to type 2 responses, with susceptibility, but this has not been studied prospectively. We studied a cohort of 631 HIV-1-infected Ugandan adults. At enrollment we performed whole blood cultures for type 1 (interferon [IFN]-gamma, interleukin [IL]-2) and type 2/immunosuppressive (IL-5, IL-10) responses to mycobacterial antigens (purified protein derivative [PPD] and culture filtrate proteins [CFP]). The incidence of tuberculosis was not associated with IFN-gamma responses, but was higher among participants with IL-2 responses (adjusted rate ratios [RR]: PPD 3.48; CFP 3.99; P < 0.001). For tuberculin skin test-positive participants, high incidence was also associated with an IL-10 response to PPD (adjusted RR 6.24, P = 0.03); for those with a BCG scar, high incidence was associated with positive IL-5 responses (adjusted RRs: PPD 3.64, P = 0.006; CFP 3.44, P = 0.04). The association with IL-2 production may reflect a response to ...Continue Reading

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Jul 21, 2004·Transactions of the Royal Society of Tropical Medicine and Hygiene·Alison M ElliottJames A G Whitworth

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Citations

Oct 14, 2009·Clinical Microbiology Reviews·Patricia PriceMartyn A French
Jan 16, 2010·The European Respiratory Journal·T OniR J Wilkinson
Apr 21, 2009·Transactions of the Royal Society of Tropical Medicine and Hygiene·Mahnaz TanveerRumina Hasan
Jun 14, 2013·Clinical & Developmental Immunology·Koen Vanden DriesscheKevin B Urdahl
Oct 16, 2007·International Journal for Parasitology·I M CattadoriP J Hudson
May 23, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Molebogeng X RangakaRobert J Wilkinson
Mar 30, 2007·Journal of Internal Medicine·D B Meya, K P W J McAdam
Mar 13, 2010·American Journal of Respiratory and Critical Care Medicine·Nontobeko G Tena-CokiBeate Kampmann
Oct 3, 2009·American Journal of Respiratory and Critical Care Medicine·Barbara KalsdorfRobert J Wilkinson
May 22, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Collin R DiedrichJoAnne L Flynn
Feb 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andreia P SoaresWillem A Hanekom

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