Abstract
Identifying correlates of immunity or susceptibility to disease promotes understanding of pathogenesis and development of diagnostic tools, treatments, and vaccines. There is evidence that type 1 cytokine responses are associated with protection against tuberculosis, and suppression of type 1, or switching to type 2 responses, with susceptibility, but this has not been studied prospectively. We studied a cohort of 631 HIV-1-infected Ugandan adults. At enrollment we performed whole blood cultures for type 1 (interferon [IFN]-gamma, interleukin [IL]-2) and type 2/immunosuppressive (IL-5, IL-10) responses to mycobacterial antigens (purified protein derivative [PPD] and culture filtrate proteins [CFP]). The incidence of tuberculosis was not associated with IFN-gamma responses, but was higher among participants with IL-2 responses (adjusted rate ratios [RR]: PPD 3.48; CFP 3.99; P < 0.001). For tuberculin skin test-positive participants, high incidence was also associated with an IL-10 response to PPD (adjusted RR 6.24, P = 0.03); for those with a BCG scar, high incidence was associated with positive IL-5 responses (adjusted RRs: PPD 3.64, P = 0.006; CFP 3.44, P = 0.04). The association with IL-2 production may reflect a response to ...Continue Reading
References
Dec 1, 1993·The Journal of Experimental Medicine·J L FlynnB R Bloom
Dec 1, 1994·Infection and Immunity·F O SánchezL F García
Nov 10, 1994·Journal of Immunological Methods·R E WeirH M Dockrell
Dec 1, 1993·The Journal of Experimental Medicine·A M CooperI M Orme
Oct 1, 1993·The Journal of Infectious Diseases·V SchaufG Kaplan
Mar 1, 1996·Infection and Immunity·J H GongP F Barnes
Mar 1, 1996·Immunology Today·T R Mosmann, S Sad
Dec 26, 1996·The New England Journal of Medicine·M J NewportM Levin
Dec 26, 1996·The New England Journal of Medicine·E JouanguyJ L Casanova
Jan 1, 1997·American Journal of Respiratory and Critical Care Medicine·J M WallaceP C Hopewell
Jan 15, 1997·Annals of Internal Medicine·N MarkowitzL B Reichman
Sep 19, 1997·The New England Journal of Medicine·C C WhalenJ J Ellner
Jan 10, 1998·Infection and Immunity·M TorresE Sada
Oct 12, 1999·JAMA : the Journal of the American Medical Association·C DyeM C Raviglione
Oct 26, 1999·Immunology Today·Z BentwichA D Beyers
Oct 26, 1999·Infection and Immunity·C OthienoZ Toossi
Oct 28, 1999·Nature·F SallustoA Lanzavecchia
Dec 23, 1999·The Journal of Infectious Diseases·G T SeahG A Rook
Jul 21, 2000·Lancet·N FrenchC F Gilks
Sep 29, 2000·Lancet·P AndersenT M Doherty
Feb 13, 2001·American Journal of Respiratory Cell and Molecular Biology·A MarchantG Del Prete
Jul 5, 2001·Lancet·A LalvaniA V Hill
Oct 12, 2001·JAMA : the Journal of the American Medical Association·G H MazurekJ S Rothel
Mar 27, 2002·Tuberculosis·S M SmithH M Dockrell
Jul 2, 2002·Lancet·Elizabeth L CorbettRichard J Hayes
Jul 13, 2002·European Journal of Immunology·Christian LienhardtGianfranco Del Prete
Aug 30, 2002·Trends in Immunology·Peter McGuirk, Kingston H G Mills
Jul 21, 2004·Transactions of the Royal Society of Tropical Medicine and Hygiene·Alison M ElliottJames A G Whitworth
Citations
Dec 24, 2005·BMC Infectious Diseases·Alison M ElliottUNKNOWN Mother and Baby study team
Dec 8, 2006·The Journal of Infectious Diseases·Mecky MateeC Fordham von Reyn
Aug 30, 2007·BMC Infectious Diseases·Stephen D LawnRobin Wood
Oct 14, 2009·Clinical Microbiology Reviews·Patricia PriceMartyn A French
Oct 15, 2009·PloS One·Rabia HussainGhaffar Dawood
Jan 16, 2010·The European Respiratory Journal·T OniR J Wilkinson
Apr 21, 2009·Transactions of the Royal Society of Tropical Medicine and Hygiene·Mahnaz TanveerRumina Hasan
Jul 15, 2011·Journal of Clinical Immunology·Rabia HussainGhaffar Dawood
Dec 14, 2011·Tuberculosis·Li LiChangyou Wu
Aug 19, 2011·The Lancet Infectious Diseases·Molebogeng X RangakaMadhukar Pai
Apr 16, 2011·Lancet·Taraz SamandariCharles D Wells
Mar 26, 2004·Tropical Medicine & International Health : TM & IH·Ambrose O TalisunaThomas G Egwang
Jun 14, 2013·Clinical & Developmental Immunology·Koen Vanden DriesscheKevin B Urdahl
Sep 6, 2011·BMC Infectious Diseases·Robert TweyongyereAlison M Elliott
Apr 17, 2003·BMC Infectious Diseases·M Kaushal SharmaA Kabani
May 29, 2007·Tuberculosis·Bushra JamilRabia Hussain
Oct 16, 2007·International Journal for Parasitology·I M CattadoriP J Hudson
May 23, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Molebogeng X RangakaRobert J Wilkinson
Mar 30, 2007·Journal of Internal Medicine·D B Meya, K P W J McAdam
Jan 19, 2008·Immunology·Else Marie AggerPeter Andersen
Mar 13, 2010·American Journal of Respiratory and Critical Care Medicine·Nontobeko G Tena-CokiBeate Kampmann
Oct 12, 2007·Clinical and Vaccine Immunology : CVI·Rabia HussainGhaffar Dawood
Oct 3, 2009·American Journal of Respiratory and Critical Care Medicine·Barbara KalsdorfRobert J Wilkinson
May 22, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Collin R DiedrichJoAnne L Flynn
Feb 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andreia P SoaresWillem A Hanekom
Mar 18, 2011·Mucosal Immunology·S PerryJ Parsonnet