Cytokine secretion by peripheral blood mononuclear cells in myasthenia gravis

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Hiroaki YoshikawaMasahito Yamada

Abstract

We studied spontaneous secretion of anti-acetylcholine receptor antibody (AChRAb), IgG and cytokines by peripheral blood mononuclear cells (PBMC) from 19 MG patients without therapy and 10 normal controls. IgG secretion was higher in the culture medium of MG than in that of normal controls. AChRAb secretion was correlated with IgG secretion in MG. Interleukin (IL)-2, IL-4, IL-5, IL-6, IL-10, IL-13, interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha secreted by PBMC from MG patients were not different from those produced by those from normal controls. IgG secretion was, however, correlated with the secretions of IL-5 and IL-6 in MG. Spontaneous B cell activation was suspected in patients with MG.

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Citations

Mar 21, 2009·Journal of Neuroimmunology·Espen Homleid AlsethGeir Olve Skeie
Jan 17, 2009·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Qiang LiKeiji Kawamoto
Feb 12, 2008·Journal of Neuroimmunology·Yutaka FurukawaMasahito Yamada
Apr 27, 2013·Scandinavian Journal of Immunology·S ZhengY Zhang
Jul 21, 2004·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Yoshihiro YasukawaMasaharu Takamori
Dec 19, 2014·Autoimmunity·Vuslat YilmazGüher Saruhan-Direskeneli
Jul 4, 2017·Clinical and Experimental Immunology·M Alahgholi-HajibehzadG Saruhan-Direskeneli
Mar 14, 2007·The Neurologist·Takao MitsuiToshio Matsumoto
Dec 21, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Revital ArichaSara Fuchs
Apr 21, 2010·Autoimmunity·Rozen Le PanseSonia Berrih-Aknin
May 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sandrine Poëa-GuyonSonia Berrih-Aknin

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