Cytokine serum levels during post-transplant adverse events in 61 pediatric patients after hematopoietic stem cell transplantation

BMC Cancer
Michaela DöringIngo Müller

Abstract

Veno-occlusive disease, Graft-versus-Host disease, invasive or localized bacterial, viral and fungal infections are known as adverse events after hematopoietic stem cell transplantation representing the major cause for morbidity and mortality. Detection and differentiation of these adverse events are based on clinical symptoms and routine measurements of laboratory parameters. To identify the role of cytokines as a possible complication-marker for adverse events, 61 consecutive pediatric patients with a median age of 7.0 years who underwent hematopoietic stem cell transplantation were enrolled in this single-center retrospective study. Interleukin-1 beta (IL-1β), soluble interleukin-2 receptor (sIL-2R), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10) and tumor necrosis factor-α serum (TNF-α) levels were regularly assessed after transplantation and during transplantation related adverse events. Veno-occlusive disease was accompanied by a significant increase in levels of IL-6, IL-8 and TNF-α.Graft-versus-Host disease was associated with a significant increase of IL-10, sIL-2R, IL-6 and TNF-α, depending on the respective stage or grade. Cytokine IL-6 enabled a significant differentiation between sepsis and fung...Continue Reading

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Citations

Feb 12, 2019·American Journal of Respiratory and Critical Care Medicine·Xiaofeng ZhouBethany B Moore
Jan 14, 2020·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Erin GatzaSung Won Choi
Oct 25, 2021·The Journal of Allergy and Clinical Immunology·Linda QuatriniLorenzo Moretta

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Methods Mentioned

BETA
biopsy
enzyme linked immunosorbent assay
bronchoalveolar lavage
PCR

Software Mentioned

GraphPad Prism®
GraphPad
XLStat2010

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