Cytokine signaling modules in inflammatory responses.

Immunity
John J O'Shea, Peter J Murray

Abstract

Cytokine signaling via a restricted number of Jak-Stat pathways positively and negatively regulates all cell types involved in the initiation, propagation, and resolution of inflammation. Here, we focus on Jak-Stat signaling in three major cell types involved in inflammatory responses: T cells, neutrophils, and macrophages. We summarize how the Jak-Stat pathways in these cells are negatively regulated by the Suppressor of cytokine signaling (Socs) proteins. We emphasize that common Jak-Stat-Socs signaling modules can have diverse developmental, pro- and anti-inflammatory outcomes depending on the cytokine receptor activated and which genes are accessible at a given time in a cell's life. Because multiple components of Jak-Stat-Socs pathways are mutated or closely associated with human inflammatory diseases, and cytokine-based therapies are increasingly deployed to treat inflammation, understanding cytokine signaling will continue to advance our ability to manipulate chronic and acute inflammatory diseases.

Associated Clinical Trials

Jun 14, 2017·Yasmin Mostafa Tawfik

References

Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·J G ZhangM Baca
Jul 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·D MetcalfW S Alexander
Dec 21, 2000·Trends in Cell Biology·A O'Garra, N Arai
Mar 10, 2001·Cold Spring Harbor Symposia on Quantitative Biology·N A NicolaD J Hilton
Mar 30, 2001·The Journal of Biological Chemistry·S KamizonoA Yoshimura
Oct 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·J G ZhangN A Nicola
Oct 23, 2001·Human Mutation·L D NotarangeloR F Schumacher
May 25, 2002·European Journal of Biochemistry·Michael HörtnerSerge Haan
Jun 22, 2002·Trends in Biochemical Sciences·Benjamin T KileDouglas J Hilton
Aug 7, 2002·The Journal of Experimental Medicine·Silvia F SorianoMario Mellado
Nov 16, 2002·Immunity·Ichiko KinjyoAkihiko Yoshimura
Nov 16, 2002·Immunity·Reiko NakagawaTadamitsu Kishimoto
Apr 11, 2003·Reviews of Physiology, Biochemistry and Pharmacology·D KamimuraT Hirano
May 20, 2003·Nature Immunology·Ben A CrokerWarren S Alexander
May 20, 2003·Nature Immunology·Roland LangPeter J Murray
May 20, 2003·Nature Immunology·Hideo YasukawaAkihiko Yoshimura
Aug 23, 2003·Immunity·Jean-Louis BoulayWilliam E Paul
Sep 23, 2003·Immunity·Fengdong ChengEduardo M Sotomayor
Nov 19, 2003·The Journal of Experimental Medicine·Arihiro KanoXin-Yuan Fu
Dec 12, 2003·Nature Reviews. Immunology·Ke Shuai, Bin Liu
Mar 23, 2004·Annual Review of Immunology·Warren S Alexander, Douglas J Hilton
May 4, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Svetlana RadaevaBin Gao
May 5, 2004·Journal of Leukocyte Biology·Raymond P DonnellyHarold Dickensheets
Jun 29, 2004·Molecular Immunology·John J O'SheaFabio Candotti
Jul 3, 2004·Nature Reviews. Drug Discovery·John J O'SheaPaul S Changelian
Aug 17, 2004·Immunity·Kerstin WolkRobert Sabat
Oct 20, 2004·The Journal of Biological Chemistry·Sébastien GingrasPeter J Murray
Oct 20, 2004·The Journal of Biological Chemistry·Andrea BaetzAlexander H Dalpke
May 3, 2005·Nature Reviews. Immunology·Leonidas C Platanias

❮ Previous
Next ❯

Citations

Oct 1, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Hyuck-Se KwonJin-Kyung Kim
Jun 10, 2011·Cancer Immunology, Immunotherapy : CII·Anil Shanker, Francesco M Marincola
Jul 25, 2013·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·B J L EggenH W G M Boddeke
Jun 8, 2013·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Yasuko Furumoto, Massimo Gadina
May 19, 2010·Immunology and Cell Biology·Stacey D FinleyDavid J Klinke
Feb 7, 2012·Nature Immunology·Lauren W CollisonDario A A Vignali
Sep 20, 2012·Nature Immunology·Peter J Murray, Stephen T Smale
Nov 26, 2008·Nature Reviews. Immunology·David M Mosser, Justin P Edwards
Aug 22, 2009·Nature Reviews. Immunology·Grant McFaddenEric Bartee
Feb 20, 2013·Nature Reviews. Rheumatology·Ernest H ChoySimon A Jones
Nov 6, 2009·The New England Journal of Medicine·Erik-Oliver GlockerChristoph Klein
Dec 18, 2008·Proceedings of the National Academy of Sciences of the United States of America·Magdalena HuberMichael Lohoff
Dec 18, 2008·Proceedings of the National Academy of Sciences of the United States of America·Ciriana OrabonaPaolo Puccetti
Aug 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Michael PlattenLawrence Steinman
May 25, 2011·Proceedings of the National Academy of Sciences of the United States of America·Sandip BhattacharyyaLouis J Muglia
Mar 14, 2012·Proceedings of the National Academy of Sciences of the United States of America·Hongwei QinEtty N Benveniste
Jul 14, 2010·The Journal of Biological Chemistry·Yi-Ching OngJohn C Boothroyd
Feb 1, 2012·The Journal of Experimental Medicine·Helena BlockAlexander Zarbock
May 22, 2009·The Journal of Infectious Diseases·Subash BabuThomas B Nutman
Jul 20, 2011·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Shuhei Sakakibara, Giovanna Tosato
Aug 25, 2011·Journal of Medicinal Food·Zeynep GencBetul Demirci
Jun 1, 2011·Nucleic Acids Research·Sang-Mun ChiDougu Nam
Jan 30, 2010·Journal of Applied Physiology·Shlomit Radom-AizikDan M Cooper
Feb 15, 2011·The Journal of Clinical Investigation·Anca SindrilaruKarin Scharffetter-Kochanek
Nov 2, 2012·The Journal of Clinical Investigation·Anne BrüstleTak W Mak
Jul 3, 2010·Journal of Biomedical Science·Rasmus O Bak, Jacob G Mikkelsen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here