Cytokine storm induced by SARS-CoV-2

Clinica Chimica Acta; International Journal of Clinical Chemistry
Peipei SongChongge You

Abstract

Coronavirus disease 2019 (COVID-19), caused by the virus designated as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread widely throughout the world. Despite the strict global outbreak management and quarantine measures that have been implemented, the incidence of COVID-19 continues to rise, resulting in more than 290,000 deaths and representing an extremely serious threat to human life and health. The clinical symptoms of the affected patients are heterogeneous, ranging from mild upper respiratory symptoms to severe pneumonitis and even acute respiratory distress syndrome (ARDS) or death. Systemic immune over activation due to SARS-CoV-2 infection causes the cytokine storm, which is especially noteworthy in severely ill patients with COVID-19. Pieces of evidence from current studies have shown that the cytokine storm may be an important factor in disease progression, even leading to multiple organ failure and death. This review provides an overview of the knowledge on the COVID-19 epidemiological profile, the molecular mechanisms of the SARS-CoV-2-induced cytokine storm and immune responses, the pathophysiological changes that occur during infection, the main antiviral compounds used in treatment strateg...Continue Reading

References

Jul 8, 2003·The Journal of Pathology·Yanqing DingKaitai Yao
Jul 8, 2005·Nature·Yumiko ImaiJosef M Penninger
Jul 27, 2005·The Journal of Experimental Medicine·Jiang GuAnthony S-Y Leong
Jul 11, 2006·Nature·Etienne MeylanMichael Karin
Aug 1, 2006·Advances in Virus Research·Paul S Masters
May 21, 2008·Proceedings of the National Academy of Sciences of the United States of America·Shiori HagaYukihito Ishizaka
Jul 19, 2008·American Journal of Respiratory and Critical Care Medicine·Mark M WurfelThomas R Martin
Mar 7, 2012·Microbiology and Molecular Biology Reviews : MMBR·Jennifer R TisoncikMichael G Katze
Feb 28, 2015·Methods in Molecular Biology·Anthony R Fehr, Stanley Perlman
May 6, 2015·The Journal of Experimental Medicine·Katrina BlazekIrina A Udalova
Feb 13, 2016·Nature Reviews. Drug Discovery·Alimuddin ZumlaKwok-Yung Yuen
Mar 30, 2016·Clinical Therapeutics·Franco PandolfiPio Conti
Jun 28, 2016·Nature Reviews. Microbiology·Emmie de WitVincent J Munster
Jul 7, 2016·Immunotherapy·Toshio TanakaTadamitsu Kishimoto
Oct 25, 2016·Trends in Microbiology·Diego ForniManuela Sironi
Dec 10, 2016·Trends in Biochemical Sciences·Jianjin ShiFeng Shao
May 4, 2017·Seminars in Immunopathology·Rudragouda Channappanavar, Stanley Perlman
Dec 12, 2018·Nature Reviews. Microbiology·Jie CuiZheng-Li Shi
Feb 15, 2019·Frontiers in Microbiology·I-Yin ChenTakeshi Ichinohe
May 28, 2019·Virology Journal·Dewald Schoeman, Burtram C Fielding
Jan 25, 2020·The New England Journal of Medicine·Na ZhuUNKNOWN China Novel Coronavirus Investigating and Research Team
Feb 8, 2020·JAMA : the Journal of the American Medical Association·Dawei WangZhiyong Peng
Feb 20, 2020·Journal of Thrombosis and Haemostasis : JTH·Ning TangZiyong Sun
Feb 23, 2020·The Lancet. Respiratory Medicine·Zhe XuFu-Sheng Wang
Feb 28, 2020·The Lancet Infectious Diseases·Heshui ShiChuansheng Zheng
Feb 29, 2020·The New England Journal of Medicine·Wei-Jie GuanUNKNOWN China Medical Treatment Expert Group for Covid-19
Mar 3, 2020·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Sufang TianShu-Yuan Xiao

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Citations

Jul 28, 2020·Nutrients·Arash MoghaddamLutz Schomburg
Oct 6, 2020·Frontiers in Nutrition·Laurent Hiffler, Benjamin Rakotoambinina
Sep 10, 2020·International Journal of Molecular Sciences·Jairo Lumpuy-CastilloÓscar Lorenzo
Nov 11, 2020·Journal of Food Biochemistry·Carmen Lammi, Anna Arnoldi
Nov 18, 2020·Emerging Topics in Life Sciences·Marvin A Sackner, Jose A Adams
Nov 29, 2020·Journal of Biomolecular Structure & Dynamics·Preeti Rana SirohiAbhinav Grover
Dec 2, 2020·Nature Communications·Fatai S OladunniJordi B Torrelles
Dec 5, 2020·Pharmaceutical Patent Analyst·Hermann Am Mucke
Dec 2, 2020·International Journal of Environmental Research and Public Health·Giuseppe De NataleRenato Somma
Nov 2, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Dongqiong XiaoYi Qu
Nov 23, 2020·International Immunopharmacology·Rasoul MirzaeiSajad Karampoor
Dec 22, 2020·Free Radical Biology & Medicine·Wanyi FangJun Wang
Jan 21, 2021·Future Medicinal Chemistry·Amanda L TauberStephan M Levonis
Jan 28, 2021·International Journal of Environmental Research and Public Health·Leonardo B FurstenauNicola Luigi Bragazzi
Feb 10, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Ömer KaradaşHayrunnisa Bolay
Feb 12, 2021·Current Hypertension Reports·Rowen GovenderThajasvarie Naicker
Oct 16, 2020·Journal of Evidence-based Medicine·Daniel Melo de Oliveira CamposJonas Ivan Nobre Oliveira
Nov 14, 2020·Reviews in the Neurosciences·Milena de Barros VianaGlauce Socorro de Barros Viana
Jan 21, 2021·Arquivos brasileiros de cardiologia·Nicolas H BorgesGustavo Lenci Marques
Feb 9, 2021·Frontiers in Veterinary Science·Shuchao WangRongliang Hu
Dec 10, 2020·Vaccines·Azizul Haque, Anudeep B Pant
Dec 15, 2020·Virusdisease·Shailendra K SaxenaR K Ratho
Dec 17, 2020·Journal of Clinical Medicine·Vincenzo LaricciaSalvatore Amoroso
Feb 13, 2021·Postgraduate Medical Journal·Rania SakrMarouan Zoghbi
Feb 13, 2021·International Journal of Molecular Sciences·Hyung Muk ChoiKyoung Soo Kim
Nov 21, 2020·International Journal of Environmental Research and Public Health·Diego Fernández-LázaroJuan Mielgo-Ayuso
Jan 21, 2021·Journal of Clinical Medicine·Ruben Aquino-Martinez, Scarlette Hernández-Vigueras
Feb 9, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Dengke TianWenqiang Cao
Feb 16, 2021·Frontiers in Immunology·Tingxuan GuZigang Dong
Feb 21, 2021·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Zahra BahariGholam Hossein Meftahi
Nov 28, 2020·Bioinformatics·Gabriela A MerinoGeorgina Stegmayer
Feb 23, 2021·The Journal of Biological Chemistry·Jonathan P HutchinsonEfstratios Stratikos
Feb 16, 2021·Expert Review of Clinical Pharmacology·Harmanjit SinghAshish Kumar Kakkar
Oct 1, 2020·Viruses·Rui WangGuo-Wei Wei
Mar 6, 2021·Respirology Case Reports·Kuniko TakahashiAkiko Matsuzaki
Feb 26, 2021·International Journal of Nanomedicine·Sangiliyandi GurunathanJin-Hoi Kim
Feb 27, 2021·Journal of Ovarian Research·Sima ChaudhariKapaettu Satyamoorthy
Feb 26, 2021·Stem Cell Reports·Anand RamaniJay Gopalakrishnan
Mar 1, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Shukur Wasman SmailMuhammad Safdar

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