Cytokine storm syndrome in coronavirus disease 2019: A narrative review.

Journal of Internal Medicine
Y-M GaoB-C Liu

Abstract

Cytokine storm syndrome (CSS) is a critical clinical condition induced by a cascade of cytokine activation, characterized by overwhelming systemic inflammation, hyperferritinaemia, haemodynamic instability and multiple organ failure (MOF). At the end of 2019, the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China, and rapidly developed into a global pandemic. More and more evidence shows that there is a dramatic increase of inflammatory cytokines in patients with COVID-19, suggesting the existence of cytokine storm in some critical illness patients. Here, we summarize the pathogenesis, clinical manifestation of CSS, and highlight the current understanding about the recognition and potential therapeutic options of CSS in COVID-19.

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Methods Mentioned

BETA
glycosylation

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NCT04357366
NCT04324021
NCT04339712
NCT04330638
NCT04341584
NCT02735707
NCT04340232
NCT04346147
NCT04320277
NCT04321993

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