Cytokine/chemokine patterns connect host and viral characteristics with clinics during chronic hepatitis C.

European Journal of Medical Research
Antonios KatsounasJoerg F Schlaak

Abstract

In chronic hepatitis C virus (HCV) infection, liver tissue pathology and HCV genotype are important determinants of clinical and/or treatment-related outcome. Although consistent epidemiological and/or molecular-biological clues derived from different studies on single virus-host interactions are meanwhile published, the in vivo transcriptional responses and cellular pathways affected in >1 key aspects of the disease or treatment process are far from being understood. Microarray analysis was performed in peripheral whole blood (PB) samples from 36 therapy-naïve HCV-infected patients with known liver histology. Linear regression analysis identified gene expression profiles significantly correlating (P < 0.015) with ≥1 out of 7 variables: sustained viral response (SVR), viral non-response (NR), end of treatment viral response (ETR), viral breakthrough (VB), HCV genotype (Gt. 1 vs. Gt. 2/3), stage of hepatic fibrosis [St. 0/1 vs. St. 2/3/4] and grade of hepatic inflammation (Gr. 0/1 vs. Gr. 2/3/4). Correlation values across all seven contrasts were considered for hierarchical clustering (HCL). A total of 1,697 genes showed ≥1 significant correlation results and genes involved in cell differentiation (183), immune response (53), an...Continue Reading

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Methods Mentioned

BETA
biopsy
biopsies
PCR

Software Mentioned

DAVID
PARTEK Genomics Suite

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