Abstract
In chronic hepatitis C virus (HCV) infection, liver tissue pathology and HCV genotype are important determinants of clinical and/or treatment-related outcome. Although consistent epidemiological and/or molecular-biological clues derived from different studies on single virus-host interactions are meanwhile published, the in vivo transcriptional responses and cellular pathways affected in >1 key aspects of the disease or treatment process are far from being understood. Microarray analysis was performed in peripheral whole blood (PB) samples from 36 therapy-naïve HCV-infected patients with known liver histology. Linear regression analysis identified gene expression profiles significantly correlating (P < 0.015) with ≥1 out of 7 variables: sustained viral response (SVR), viral non-response (NR), end of treatment viral response (ETR), viral breakthrough (VB), HCV genotype (Gt. 1 vs. Gt. 2/3), stage of hepatic fibrosis [St. 0/1 vs. St. 2/3/4] and grade of hepatic inflammation (Gr. 0/1 vs. Gr. 2/3/4). Correlation values across all seven contrasts were considered for hierarchical clustering (HCL). A total of 1,697 genes showed ≥1 significant correlation results and genes involved in cell differentiation (183), immune response (53), an...Continue Reading
References
Dec 1, 1995·The American Journal of Surgical Pathology·K P Batts, J Ludwig
Mar 1, 1997·Journal of Hepatology·M ShindoT Okuno
May 9, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·L E JensenA S Whitehead
Oct 5, 2001·Lancet·M P MannsJ K Albrecht
Apr 20, 2002·Current Opinion in Infectious Diseases·M HeydtmannD Adams
May 3, 2002·Clinical and Experimental Immunology·S WardP Klenerman
Aug 6, 2002·Frontiers in Bioscience : a Journal and Virtual Library·Fabio Marra
Apr 2, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Bin GaoSvetlana Radaeva
Aug 31, 2004·Oncogene·Pei-Lin ChengYan-Hwa Wu Lee
Sep 16, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hermann E WasmuthFrank Lammert
Apr 6, 2007·The New England Journal of Medicine·Margaret James Koziel, Marion G Peters
Aug 24, 2007·Developmental Biology·Jennifer Jemc, Ilaria Rebay
Oct 6, 2007·Gastroenterology·Angela DolganiucGyongyi Szabo
Jan 10, 2009·Nature Protocols·Da Wei HuangRichard A Lempicki
Jun 16, 2010·PloS One·Henning W ZimmermannFrank Tacke
Citations
Aug 13, 2013·PloS One·Kristi HuikIrja Lutsar
Aug 12, 2014·PloS One·Lawrence M PfefferCharles R Handorf
Oct 1, 2016·Mediators of Inflammation·Guilherme de Paula CostaAndre Talvani