Cytokines and autoimmunity

Nature Reviews. Immunology
John J O'SheaPeter Lipsky

Abstract

Cytokines have crucial functions in the development, differentiation and regulation of immune cells. As a result, dysregulation of cytokine production or action is thought to have a central role in the development of autoimmunity and autoimmune disease. Some cytokines, such as interleukin-2, tumour-necrosis factor and interferons--ostensibly, the 'bad guys' in terms of disease pathogenesis--are well known for the promotion of immune and inflammatory responses. However, these cytokines also have crucial immunosuppressive functions and so, paradoxically, can also be 'good guys'. The balance between the pro-inflammatory and immunosuppressive functions of these well-known cytokines and the implications for the pathogenesis of autoimmune disease is the focus of this review.

References

Jun 27, 1998·Lupus·J C Crispin, J Alcocer-Varela
Jan 23, 1999·Current Opinion in Immunology·A P Cope
Jun 22, 1999·Current Opinion in Immunology·M A OosterwegelA H Sharpe
Aug 18, 1999·Immunological Reviews·Y RefaeliA K Abbas
Jan 13, 2000·Current Opinion in Immunology·E A Green, R A Flavell
Jan 13, 2000·Current Opinion in Immunology·M Falcone, N Sarvetnick
May 3, 2000·British Journal of Haematology·E GrunebaumC M Roifman
Jul 6, 2000·Pediatric Research·C M Roifman
Mar 23, 2001·Nature Immunology·J J O'Shea, R Visconti
Jul 21, 2000·Arthritis and Rheumatism·Y Ioannou, D A Isenberg
Aug 26, 2000·Current Biology : CB·E M Shevach
Nov 23, 2000·Genes & Development·H L HsuD J Chen
Dec 29, 2000·Pediatric Clinics of North America·J J BleesingT A Fleisher
Feb 15, 2001·Nature Medicine·T OwensJ Antel
Mar 20, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·A SkapenkoH Schulze-Koops
Apr 20, 2001·Seminars in Respiratory Infections·S M Holland
Apr 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M K LevingsM G Roncarolo
May 24, 2001·Current Opinion in Neurology·C L KarpL Nagelkerken
Jun 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·U ChristenM G von Herrath
Jun 19, 2001·Current Opinion in Immunology·M GadinaJ J O'Shea
Jun 20, 2001·The Journal of Clinical Investigation·I K CampbellI P Wicks
Jul 7, 2001·The New England Journal of Medicine·G M Lauer, B D Walker
Aug 2, 2001·Nature Medicine·P MarrackB L Kotzin
Aug 4, 2001·The New England Journal of Medicine·A Davidson, B Diamond
Aug 31, 2001·Nature Genetics·C Miceli-RichardJ P Hugot
Sep 18, 2001·Lancet·L C Stene, P Nafstad
Dec 26, 2001·Proceedings of the National Academy of Sciences of the United States of America·A A LighvaniJ J O'Shea
Jan 10, 2002·Genes and Immunity·D M FruchtF Candotti

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Citations

Jun 5, 2008·Inflammatory Bowel Diseases·Jesús Rivera-NievesKlaus Ley
Feb 4, 2005·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·K Greiner, J Plskova
Aug 26, 2010·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Arnd HeiligenhausGerhild Wildner
Apr 8, 2010·Cancer Causes & Control : CCC·Yian GuAnne Zeleniuch-Jacquotte
Jun 21, 2006·Journal of Clinical Immunology·Eddie T ChiangFarhad Imani
Sep 11, 2007·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Xiaoyi ChenXiufa Sun
Apr 12, 2007·Current Diabetes Reports·Georgia FousteriDamien Bresson
Sep 10, 2004·Current Rheumatology Reports·Robert H Carter
Jan 4, 2008·Immunologic Research·Zhi Chen, John J O'Shea
Apr 6, 2004·Current Opinion in Pharmacology·Samir E AlamKamal F Badr
Mar 25, 2004·Trends in Immunology·Giuseppe Matarese, Antonio La Cava
Aug 2, 2003·Journal of the American Academy of Dermatology·Alice B Gottlieb
Mar 20, 2004·Brain & Development·Eun Sook ParkJeon-Soo Shin
Aug 29, 2003·The Journal of Steroid Biochemistry and Molecular Biology·Tomoshige KinoGeorge P Chrousos
Sep 11, 2002·Cytokine & Growth Factor Reviews·Toshio Hirano
May 24, 2003·Trends in Molecular Medicine·Giuseppe MatareseCarlo Alviggi
Dec 5, 2012·Analytical Chemistry·Yvonne J YamanakaJ Christopher Love
Mar 8, 2008·Nature Medicine·Arian LaurenceWendy T Watford
Nov 6, 2013·Nature Reviews. Rheumatology·Cornelia M Weyand, Jörg J Goronzy
Oct 9, 2002·The Journal of Experimental Medicine·Toru AtsumiToshio Hirano
Jan 5, 2005·The Journal of Experimental Medicine·Hye Young KimDoo Hyun Chung
Feb 11, 2009·The Journal of Experimental Medicine·Heather R ContiSarah L Gaffen
Nov 30, 2006·DNA and Cell Biology·Anahit GhochikyanDavid H Cribbs
Aug 10, 2011·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Balaji B GaneshBellur S Prabhakar
Sep 29, 2011·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Kamal D Moudgil, Divaker Choubey
Apr 7, 2012·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Giuseppe MurdacaFrancesco Puppo
Jun 24, 2003·Current Opinion in Rheumatology·John J O'SheaFabio Candotti
May 18, 2006·Molecular and Cellular Biology·Ryoko Ishida-TakahashiMartin G Myers

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