Cytokines and chemokines differentially regulate innate immune cell trafficking during post kala-azar dermal leishmaniasis

Journal of Cellular Biochemistry
Ashish Kumar SinghS Bimal

Abstract

Post kala-azar dermal leishmaniasis (PKDL) is often considered to be the anthroponotic reservoir of visceral leishmaniasis (VL) in India. A better understanding of the host immune-response in dermal lesions of PKDL patients is therefore of utmost significance to minimize such patients and to restrict VL transmission. Although the innate immune response is known to play an important role in parasite clearance from dermal lesions, the actual contribution of innate cells to the pathogenicity of PKDL is poorly understood. The present study explored the immune-pathogenesis of PKDL patients to understand the expression of CD62L, CD11b, CXCL8/IL-8, and MIP1-α and their contribution in signaling during innate cell trafficking. Twenty-five individuals were enrolled, who comprised eight active and untreated macular cases, seven active and untreated cases with papulo-nodular PKDL manifestations, five successfully treated post PKDL cases and five healthy individuals from a non-endemic region of Bihar, India. The immunological investigation was performed on biopsy specimens prepared with a disaggregation technique and blood samples. We observed that the PMNs in nodular patients displayed decreased L-selectin (CD62L) levels and increased int...Continue Reading

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Citations

Nov 15, 2018·Environmental Science and Pollution Research International·Caroline PeruzziSolange Cristina Garcia
Oct 15, 2019·Frontiers in Cellular and Infection Microbiology·Fatima Conceição-Silva, Fernanda N Morgado
Oct 12, 2020·Cytokine·Abdollah JafarzadehMaryam Nemati
Dec 12, 2020·Cytokine·Fernanda Fortes de AraújoAndréa Teixeira-Carvalho

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