Cytokines and clustered cardiovascular risk factors in children

Metabolism: Clinical and Experimental
Lars Bo AndersenRobert G McMurray

Abstract

The aim was to evaluate the possible role of tumor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6), C-reactive protein (CRP), low fitness, and fatness in the early development of clustering of cardiovascular disease (CVD) risk factors and insulin resistance. Subjects for this cross-sectional study were obtained from 18 schools near Copenhagen, Denmark. Two hundred ten 9-year-old children were selected for cytokine analysis from 434 third-grade children with complete CVD risk profiles. The subgroup was selected according to the CVD risk factor profile (upper and lower quartile of a composite CVD risk score). All the CVD risk factors and CRP differed between the high- and low-risk groups; but plasma glucose, TNF-alpha, and IL-6 had small and inconsistent differences. Strong associations were found between CVD risk scores and fitness (VO(2peak)) or fatness. No associations were found between CVD risk scores and TNF-alpha and IL-6. C-reactive protein was associated with fitness, fatness, and CVD risk score. This study does not support an association between plasma IL-6 or TNF-alpha and low insulin sensitivity or clustering of CVD risk factors in a young cohort. Inflammation was more pronounced in fat and unfit children base...Continue Reading

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Citations

Feb 18, 2012·JAMA : the Journal of the American Medical Association·Ulf EkelundUNKNOWN International Children's Accelerometry Database (ICAD) Collaborators
Mar 27, 2013·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·R Dalla Pozza
Jul 19, 2013·Journal of Obesity·Ulla SovioSanjay Kinra
Aug 29, 2013·BioMed Research International·Duncan S BuchanJulien S Baker
Jun 24, 2015·European Journal of Pediatrics·Breno Quintella FarahRaphael Mendes Ritti-Dias
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May 17, 2018·Pediatric Cardiology·Breno Quintella FarahRaphael Mendes Ritti-Dias
Sep 13, 2017·European Journal of Applied Physiology·César A Agostinis-SobrinhoRute Santos
Sep 18, 2018·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·M KamelL N Anderson
Jan 4, 2017·BioMed Research International·Julien S BakerDanilo S Bocalini
Nov 28, 2017·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·César Agostinis-SobrinhoRute Santos

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