PMID: 8967784Mar 1, 1996Paper

Cytokines and growth factors influence hair growth in vitro. Possible implications for the pathogenesis and treatment of alopecia areata

Archives of Dermatological Research
R HoffmannR Happle

Abstract

Factors that influence the growth of the anagen hair follicle or initiate the switch to a catagen growth pattern have so far not been definitely determined, but there is increasing evidence that cytokines and growth factors play an important role during these processes. Recently we detected an aberrant in situ expression pattern of cytokines of the Th1 type (IFN gamma, IL-2) plus IL-1 beta expression in untreated alopecia areata (AA), and a switch to high levels of IL-10 TGF-beta 1 expression after successful treatment with the contact allergen diphenylcyclopropenone (DCP). Hence the question arose as to whether cytokines are able to arrest hair growth and whether IL-10 or TGF beta 1 have the capacity to antagonize this process. Using whole-organ cultures of microdissected human hair follicles we studied the effect of a panel of cytokines and growth factors on hair growth and on the gross morphology of the hair follicles in vitro. IL-2, IL-10 and IFN-gamma had no effect in this regard, whereas TGF beta 1 partially inhibited hair growth and EGF, TNF alpha and IL-1 beta completely abrogated it. EGF and TNF alpha induced the formation of a club-like hair follicle, similar to catagen morphology of the hair bulb, whereas hair follic...Continue Reading

References

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Citations

Jun 2, 2005·Journal of the American Academy of Dermatology·Bruce E StroberJerome L Shupack
Mar 22, 2000·Journal of the American Academy of Dermatology·S Madani, J Shapiro
Jun 9, 2001·Clinics in Dermatology·M DuvicM de Andrade
Mar 10, 2001·Journal of Dermatological Science·T FujieS Arase
Nov 9, 2000·The British Journal of Dermatology·R RückertR Paus
Nov 10, 2015·Expert Review of Clinical Immunology·Hongwei GuoKevin McElwee
Jan 19, 2006·The Journal of Investigative Dermatology·Natalia V BotchkarevaDouglas Shander
Dec 7, 2007·The American Journal of Pathology·Eva M J PetersRalf Paus
Feb 3, 2007·International Journal of Dermatology·Dan WassermanAmy McMichael
Mar 1, 2014·International Journal of Rheumatic Diseases·Luisa CostaRaffaele Scarpa
Mar 30, 2010·The British Journal of Dermatology·M GhoreishiJ P Dutz
Jul 7, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Andreas Lauterbach, Christel C Müller-Goymann
Sep 26, 2013·ELife·Ainhoa Pérez-GarijoHermann Steller
Apr 23, 2017·Journal of Cosmetic Dermatology·Murat TurkogluHakan Sevinc
May 10, 2012·Anais Brasileiros De Dermatologia·Gleison Vieira Duarte
Jun 24, 2008·The International Journal of Clinical and Experimental Hypnosis·Ria Willemsen, Johan Vanderlinden
Apr 1, 1997·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M SeibergS S Shapiro
Aug 6, 2021·ImmunoTargets and Therapy·Poonkiat SuchonwanitCherrin Pomsoong
Oct 10, 2021·Tissue Engineering and Regenerative Medicine·Jung Min ParkJi Won Oh

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