Cytokines and immunodeficiency diseases

Nature Reviews. Immunology
W J Leonard

Abstract

Severe combined immunodeficiency disease (SCID) refers to a spectrum of inherited immunodeficiencies that together represent the most severe forms of primary immunodeficiency in humans. Recent work has shown that many of these diseases, as well as other forms of immunodeficiency, result from defects in cytokine signalling pathways. Such defects can prevent normal development of lymphoid lineages and/or compromise cytokine signalling by these cells. These natural 'experiments' in human genetics have shown the non-redundant role for several cytokines or cytokine signalling molecules. Moreover, a comparison of the phenotypes of humans with SCID to analogous mouse-knockout models has shown not only expected similarities, but also unexpected differences in cytokine signalling between humans and mice.

References

Jul 17, 1992·Science·T TakeshitaK Sugamura
Nov 1, 1991·Science·R KühnW Müller
Oct 1, 1990·Immunology Today·J F Bazan
Jun 14, 1990·The New England Journal of Medicine·K Weinberg, R Parkman
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R PahwaR A Good
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·G de Saint BasileC Griscelli
Nov 3, 1995·Science·T NosakaJ N Ihle
Jan 1, 1995·International Immunology·Y KimuraK Sugamura
Jan 17, 1995·Proceedings of the National Academy of Sciences of the United States of America·J P DiSantoK Rajewsky
Nov 1, 1994·The Journal of Experimental Medicine·J J PeschonB L Davison
Jan 15, 1997·Genes & Development·X LiuL Hennighausen
Apr 1, 1997·Current Opinion in Cell Biology·C M Horvath, J E Darnell
Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·N SharfeC M Roifman
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·K TakedaS Akira
Jan 1, 1997·Annual Review of Immunology·A FischerF Le Deist
Jul 8, 1997·Proceedings of the National Academy of Sciences of the United States of America·G B UdyH W Davey

❮ Previous
Next ❯

Citations

Apr 25, 2012·Journal of Assisted Reproduction and Genetics·Reut Tomashov-MatarMordechai Shohat
Jan 26, 2012·Immunologic Research·Yanlu Zhang, Baohua Zhou
Oct 23, 2004·Best Practice & Research. Clinical Haematology·Michel SadelainIsabelle Rivière
Sep 24, 2013·Trends in Immunology·Jianhua YuMichael A Caligiuri
Dec 6, 2003·The Journal of Allergy and Clinical Immunology·Tania HabibKenneth Kaushansky
Aug 7, 2002·International Journal of Cardiology·Klaus K A Witte, Andrew L Clark
Aug 7, 2002·International Journal of Cardiology·Rakesh Sharma, Stefan D Anker
Mar 29, 2003·Journal of Hepatology·Kim R BridleGrant A Ramm
Sep 1, 2009·Bone Marrow Transplantation·A MeguroK Ozawa
Mar 31, 2010·Immunology and Cell Biology·Sandrine DubracSusanne Ebner
Nov 6, 2013·Immunology and Cell Biology·Alvin Pratama, Carola G Vinuesa
Sep 14, 2004·Nature Immunology·Hai-Hui XueWarren J Leonard
Sep 3, 2005·Nature Reviews. Immunology·Warren J Leonard, Rosanne Spolski
Jun 23, 2009·Nature Reviews. Immunology·Yrina RochmanWarren J Leonard
Jul 28, 2010·The New England Journal of Medicine·Salima Hacein-Bey-AbinaMarina Cavazzana-Calvo
May 20, 2011·Proceedings of the National Academy of Sciences of the United States of America·Lu WangWarren J Leonard
Oct 2, 2002·Proceedings of the National Academy of Sciences of the United States of America·Hai-Hui XueWarren J Leonard
Jul 21, 2004·The Journal of Experimental Medicine·Amin Al-ShamiWarren J Leonard
Jan 5, 2005·The Journal of Experimental Medicine·Rong ZengWarren J Leonard
Mar 16, 2005·The Journal of Experimental Medicine·Sheila DiasPaulo Vieira
Sep 21, 2005·The Journal of Experimental Medicine·Amin Al-ShamiWarren J Leonard
Jan 18, 2007·The Journal of Experimental Medicine·Alejandro V VillarinoChristopher A Hunter
Nov 25, 2003·Current Opinion in Pediatrics·Jonathan W Heusel, Zuhair K Ballas
Nov 19, 2004·Current Opinion in Pediatrics·Capucine Picard, Jean-Laurent Casanova
May 31, 2012·Open Biology·Clive MetcalfeA Neil Barclay
Mar 26, 2003·Genes & Development·Leonardo SalmenaRazqallah Hakem
Sep 27, 2008·Annual Review of Immunology·Xinquan WangK Christopher Garcia
Oct 24, 2007·Annual Review of Immunology·Rosanne Spolski, Warren J Leonard
Jan 5, 2008·Annual Review of Immunology·Cecile KingCharles R Mackay
Dec 8, 2007·Annual Review of Immunology·Thomas R Malek
Aug 21, 2013·Clinical & Developmental Immunology·Andrzej Przemysław HermanDorota Tomaszewska-Zaremba
Jul 16, 2005·Blood·Kunihiro YamaokaJohn J O'shea
Jan 20, 2007·Blood·Rong ZengWarren J Leonard
Oct 17, 2007·Blood·Jian-Xin LinWarren J Leonard
Jun 27, 2008·Blood·Danielle T AveryStuart G Tangye

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.